Protein detail

PDGFC

Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]

Entry name
PDGFC
UniProt ID
Q9NRA1
EVMP confidence score
0.63
Supporting publications (n)
9
Transmembrane count
Protein classification
Predicted secreted proteinsRAS pathway related proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]
Protein Class (2)
Predicted secreted proteinsRAS pathway related proteins
Protein Function (2)
  • Predicted secreted proteins
  • RAS pathway related proteins
Ensembl
ENSG00000145431
Entrez Gene Symbol
PDGFC
Gene Synonym (2)
falloteinSCDGF
Gene Description
Platelet derived growth factor C
Chromosome
4
Position
156760454-156971799
Supporting publications (n)
9
EVMP confidence score
0.63
Fluorescence & Localization4
PDGFC fluorescence
Cell SpecificEpididymal principal cellsBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway7
Protein Function (2)
  • Predicted secreted proteins
  • RAS pathway related proteins
Cellular Component (9)
Molecular Function (4)
Biological Process (3)
KEGG (14)
Page 1 of 2
Reactome (2)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence58

Ligand-Receptor Signaling (49)

49 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorGO_IntercellNoYesYesNoNo
receptorreceptorOmniPathNoYesYesNoNo
extracellularextracellularHPMRNoNoYesNoNo
extracellularextracellularOmniPathNoNoYesNoNo
intracellularintracellularComPPINoNoYesNoNo
intracellularintracellularGO_IntercellNoNoYesNoNo
intracellularintracellularUniProt_locationNoNoYesNoNo
intracellularintracellularOmniPathNoNoYesNoNo
cell_surface_ligandcell_surface_ligandCellPhoneDBYesNoYesNoNo
cell_surface_ligandcell_surface_ligandOmniPathYesNoYesNoNo
Page 1 of 5Next

Regulatory Interaction Network (2)

2 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PDGFCQ9NRA1PGFRAP16234YesYesNoiTALKICELLNETHINTSignaLink3DIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbHPRD:11342471connectomeDB2020:11297552connectomeDB2020:10806482Baccin2019:11342471Cellinker:28267575ICELLNET:9739761LRdb:11342471HPRD:10806482SignaLink3:10806482HINT:11297552HPMR:15207811CellChatDB:15207812DIP:20534510IntAct:20534510IntAct:11297552LRdb:10806482SignaLink3:18988627Cellinker:15207812HPMR:10806482SignaLink3:23331499connectomeDB2020:11342471SignaLink3:11297552Baccin2019:10806482DIP:11297552Baccin2019:11297552SignaLink3:21071413IntAct:10806482LRdb:11297552ICELLNET:15207811HINT:20534510SignaLink3:11342471HINT:10806482CellTalkDB:10806482HPRD:11297552
PDGFCQ9NRA1PGFRBP09619YesYesNoFantom5_LRdbCellTalkDBiTALKtalklrconnectomeDB2020SignaLink3Baccin2019WangLRdbSTRING_talklrEMBRACECellCallSignaLink3:11297552Baccin2019:19795151SignaLink3:23331499CellTalkDB:32196115connectomeDB2020:19795151

Protein Complex Composition (6)

6 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
Platelet-derived growth factor CC complexPDGFCQ9NRA11ComplexPortalintact:EBI-90794741475529215207811
CREB3OGTPDGFCO15294O43889Q9NRA10:0:0hu.MAP2
CREB3DPY30HCFC1PDGFCTHAP11THAP2O43889P51610Q96EK4Q9C005Q9H0W7Q9NRA10:0:0:0:0:0hu.MAP2
BLTP3ACREB3CREB3L2PDGFCO43889Q6BDS2Q70SY1Q9NRA10:0:0:0hu.MAP
BLTP3ACREB3PDGFCO43889Q6BDS2Q9NRA10:0:0hu.MAP2
CREB3PDGFCO43889Q9NRA10:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry23754552537648786
Sequence, Structure & Domains8

Sequences

Length
345
Mass
39,029
Sequence
MSLFGLLLLTSALAGQRQGTQAESNLSSKFQFSSNKEQNGVQDPQHERIITVSTNGSIHSPRFPHTYPRNTVLVWRLVAVEENVWIQLTFDERFGLEDPEDDICKYDFVEVEEPSDGTILGRWCGSGTVPGKQISKGNQIRIRFVSDEYFPSEPGFCIHYNIVMPQFTEAVSPSVLPPSALPLDLLNNAITAFSTLEDLIRYLEPERWQLDLEDLYRPTWQLLGKAFVFGRKSRVVDLNLLTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEECDCVCRGSTGG
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NRA1-1; Sequence=Displayed; Name=2; IsoId=Q9NRA1-2; Sequence=VSP_034703; Name=3; IsoId=Q9NRA1-3; Sequence=VSP_034701, VSP_034702; Name=4; IsoId=Q9NRA1-4; Sequence=VSP_047606
Alternative Sequence
1..163; Missing (in isoform 4); 155..167; GFCIHYNIVMPQF -> SNRGGKIIQLHTS (in isoform 3); 168..345; Missing (in isoform 3); 244..306; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)
46..163; CUB
Protein Families
PDGF/VEGF growth factor family
Sequence Similarities
Belongs to the PDGF/VEGF growth factor family.
Clinical Relevance5
Drugs
SUNITINIB
Antibody
HPA009134
Interaction Protein
ENSG00000134853
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications9
PMIDTitleAbstract
28102751Extracellular vesicles from activated platelets: a semiquantitative cryo-electron microscopy and immuno-gold labeling study.According to the current model, EVs shed from the plasma membrane, often called microvesicles, expose phosphatidylserine (PS) and range in size from 100 nm to 1 µm, while EVs originating from endosomal multi-vesicular bodies, called exosomes, contain tetraspanin proteins, including CD63, and range in size from 50 to 100 nm.
28823103Bariatric Surgery Is Accompanied by Changes in Extracellular Vesicle-Associated and Plasma Fatty Acid Binding Protein 4.EV origin (CD9: exosome; CD41: platelet; CD235a: erythrocyte; CD11b: leukocyte; CD144: endothelial), cytokine (interferon γ, interleukin-6, TNF-α) and adipocyte marker (adiponectin, FABP4, PPARγ) expression was measured by time-resolved fluorescence immunoassay.
29845758Low cardiorespiratory fitness is associated with higher extracellular vesicle counts in obese adults.Extracellular vesicles (EVs) are a novel target of CVD, however, it remains unknown if obese individuals with very poor fitness (VPF) have elevated EVs versus people with poor fitness (PF).
32341357CD41-deficient exosomes from non-traumatic femoral head necrosis tissues impair osteogenic differentiation and migration of mesenchymal stem cells.Taken together, our study results revealed that in the progress of ONFH, exosomes from the pathological bone brought about the failure of MSCs repairing the necrotic bone for lack of some critical proteins, like integrin CD41, and prompted the progression of experimentally induced ONFH-like status in the rat.
33345458Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays.LC-MS/MS analysis identified a protein band precipitated by rPALa as CD61, a marker of platelet-derived exosomes (P-Exo).
34224189Amphibian thrombocyte-derived extracellular vesicles, including microRNAs, induce angiogenesis-related genes in endothelial cells.Here, we report the finding that thrombocytes produce integrin alpha IIb (CD41)-positive extracellular vesicles (EVs), which include microRNAs (miRs).
34979484Plasma-derived extracellular vesicles from myocardial infarction patients inhibits tumor necrosis factor-alpha induced cardiac cell death.No abstract available
35350978CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma.No abstract available
35811733Circulating Small Extracellular Vesicles Profiling and Thrombin Generation as Potential Markers of Thrombotic Risk in Glioma Patients.This study aimed to evaluate the relative abundance of extracellular vesicles (EVs) and thrombin generation (TG) in combination with standard laboratory tests in patients with newly diagnosed GM as potential prognostic markers in VTE.