EV MemProt Atlas

Basic Information

Protein Names

Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]

Protein Class

Predicted secreted proteinsRAS pathway related proteins

Protein Function

Predicted secreted proteins
RAS pathway related proteins

Ensembl

ENSG00000145431

Entrez Gene Symbol

PDGFC

Gene Synonym

falloteinSCDGF

Gene Description

Platelet derived growth factor C

Chromosome

4

Position

156760454-156971799

Frequency

9

EVMP Score

0.63

Fluorescence & Localization

Cell SpecificEpididymal principal cellsBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Predicted secreted proteins
RAS pathway related proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Metabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
growth_factor	ligand	iTALK	Yes	No	Yes	No	No
ligand	ligand	EMBRACE	Yes	No	Yes	No	No
ligand	ligand	CellPhoneDB	Yes	No	Yes	No	No
ligand	ligand	GO_Intercell	Yes	No	Yes	No	No
ligand	ligand	ICELLNET	Yes	No	Yes	No	No
ligand	ligand	CellChatDB	Yes	No	Yes	No	No
ligand	ligand	CellTalkDB	Yes	No	Yes	No	No
ligand	ligand	Ramilowski2015	Yes	No	Yes	No	No
ligand	ligand	Guide2Pharma	Yes	No	Yes	No	No
growth_factor	ligand	DGIdb	Yes	No	Yes	No	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PDGFC	Q9NRA1	PGFRA	P16234	Yes	Yes	No	iTALKICELLNETHINTSignaLink3DIPHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDIntActRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HPRD:11342471 connectomeDB2020:11297552 connectomeDB2020:10806482 Baccin2019:11342471 Cellinker:28267575 ICELLNET:9739761 LRdb:11342471 HPRD:10806482 SignaLink3:10806482 HINT:11297552 HPMR:15207811 CellChatDB:15207812 DIP:20534510 IntAct:20534510 IntAct:11297552 LRdb:10806482 SignaLink3:18988627 Cellinker:15207812 HPMR:10806482 SignaLink3:23331499 connectomeDB2020:11342471 SignaLink3:11297552 Baccin2019:10806482 DIP:11297552 Baccin2019:11297552 SignaLink3:21071413 IntAct:10806482 LRdb:11297552 ICELLNET:15207811 HINT:20534510 SignaLink3:11342471 HINT:10806482 CellTalkDB:10806482 HPRD:11297552
PDGFC	Q9NRA1	PGFRB	P09619	Yes	Yes	No	Fantom5_LRdbCellTalkDBiTALKtalklrconnectomeDB2020SignaLink3Baccin2019WangLRdbSTRING_talklrEMBRACECellCall	SignaLink3:11297552 Baccin2019:19795151 SignaLink3:23331499 CellTalkDB:32196115 connectomeDB2020:19795151

Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Platelet-derived growth factor CC complex	PDGFC	Q9NRA1	1	ComplexPortal	intact:EBI-9079474	14755292 15207811
	CREB3 OGT PDGFC	O15294 O43889 Q9NRA1	0:0:0	hu.MAP2
	CREB3 DPY30 HCFC1 PDGFC THAP11 THAP2	O43889 P51610 Q96EK4 Q9C005 Q9H0W7 Q9NRA1	0:0:0:0:0:0	hu.MAP2
	BLTP3A CREB3 CREB3L2 PDGFC	O43889 Q6BDS2 Q70SY1 Q9NRA1	0:0:0:0	hu.MAP
	BLTP3A CREB3 PDGFC	O43889 Q6BDS2 Q9NRA1	0:0:0	hu.MAP2
	CREB3 PDGFC	O43889 Q9NRA1	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	37545525 37648786

Sequence, Structure & Domains

Sequences

Length

345

Mass

39,029

Sequence

MSLFGLLLLTSALAGQRQGTQAESNLSSKFQFSSNKEQNGVQDPQHERIITVSTNGSIHSPRFPHTYPRNTVLVWRLVAVEENVWIQLTFDERFGLEDPEDDICKYDFVEVEEPSDGTILGRWCGSGTVPGKQISKGNQIRIRFVSDEYFPSEPGFCIHYNIVMPQFTEAVSPSVLPPSALPLDLLNNAITAFSTLEDLIRYLEPERWQLDLEDLYRPTWQLLGKAFVFGRKSRVVDLNLLTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEECDCVCRGSTGG

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NRA1-1; Sequence=Displayed; Name=2; IsoId=Q9NRA1-2; Sequence=VSP_034703; Name=3; IsoId=Q9NRA1-3; Sequence=VSP_034701, VSP_034702; Name=4; IsoId=Q9NRA1-4; Sequence=VSP_047606

Alternative Sequence

1..163; Missing (in isoform 4); 155..167; GFCIHYNIVMPQF -> SNRGGKIIQLHTS (in isoform 3); 168..345; Missing (in isoform 3); 244..306; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (FT)

46..163; CUB

Protein Families

PDGF/VEGF growth factor family

Sequence Similarities

Belongs to the PDGF/VEGF growth factor family.

Clinical Relevance

Drugs

SUNITINIB

Antibody

HPA009134

Interaction Protein

ENSG00000134853

Interaction Count

1

Interaction Dataset

intact_biogrid

Protein symbol PDGFC	UniProt ID Q9NRA1	EVMP score 0.63
Frequency 9	Transmembrane count	Protein classification Predicted secreted proteinsRAS pathway related proteins