Protein detail
LRC4B
Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)
Entry name LRC4B | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)
Protein Class (3)
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
577..597; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
DKFZp761A179HSMLRIG4
Gene Description
Leucine rich repeat containing 4B
Chromosome
19
Position
50516892-50568435
Supporting publications (n)
6
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway7
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (5)
Molecular Function
Biological Process (3)
Reactome (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence46
Ligand-Receptor Signaling (42)
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | Yes | Yes | No |
| lrr_ig | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| extracellular | extracellular | HPMR | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | Yes | Yes | No |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRF | P10586 | LRC4B | Q9NT99 | Yes | Yes | No | Wojtowicz2020SIGNORBaccin2019 | SIGNOR:19467332 |
| LRC4B | Q9NT99 | DLG4 | P78352 | Yes | Yes | No | SIGNOR | SIGNOR:19467332 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37707705 |
Sequence, Structure & Domains8
Sequences
Length
713
Mass
76,434
Sequence
MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI
Domain & Motif Annotations
Compositional Bias
528..546; Low complexity; 703..713; Basic and acidic residues
Repeat
87..108; LRR 1; 111..132; LRR 2; 135..156; LRR 3; 159..180; LRR 4; 183..205; LRR 5; 208..229; LRR 6; 230..251; LRR 7; 254..275; LRR 8; 278..299; LRR 9
Domain (CC)
The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4..
Domain (FT)
48..86; LRRNT; 311..363; LRRCT; 364..452; Ig-like C2-type
Region
497..551; Disordered; 694..713; Disordered
Clinical Relevance1
Antibody
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 30451371 | Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No abstract available |
| 38136601 | Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study. | No abstract available |
| 40619995 | A 96-Well Ultrafiltration Approach for the High-Throughput Proteome Analysis of Extracellular Vesicles Isolated From Conditioned Medium. | No abstract available |
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |