Protein detail
LRC4B
Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)
Entry name LRC4B | UniProt ID | EVMP score 0.38 |
Frequency 6 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
577..597; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp761A179HSMLRIG4
Gene Description
Leucine rich repeat containing 4B
Chromosome
19
Position
50516892-50568435
Frequency
6
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | Yes | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRF | P10586 | LRC4B | Q9NT99 | Yes | Yes | No | Wojtowicz2020SIGNORBaccin2019 | SIGNOR:19467332 |
| LRC4B | Q9NT99 | DLG4 | P78352 | Yes | Yes | No | SIGNOR | SIGNOR:19467332 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37707705 |
Sequence, Structure & Domains
Sequences
Length
713
Mass
76,434
Sequence
MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI
3D Structural Models
Domain & Motif Annotations
Compositional Bias
528..546; Low complexity; 703..713; Basic and acidic residues
Repeat
87..108; LRR 1; 111..132; LRR 2; 135..156; LRR 3; 159..180; LRR 4; 183..205; LRR 5; 208..229; LRR 6; 230..251; LRR 7; 254..275; LRR 8; 278..299; LRR 9
Domain (CC)
The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4..
Domain (FT)
48..86; LRRNT; 311..363; LRRCT; 364..452; Ig-like C2-type
Region
497..551; Disordered; 694..713; Disordered
Clinical Relevance
Antibody