Protein detail

T106B

Transmembrane protein 106B

Entry name
T106B
UniProt ID
Q9NUM4
EVMP confidence score
0.28
Supporting publications (n)
2
Transmembrane count
1
Protein classification
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Transmembrane protein 106B
Protein Class (6)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
  • Transporters
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Potential drug targets
  • Disease related genes
Transmembrane
97..117; Helical
Transmembrane Count
1
Ensembl
ENSG00000106460
Entrez Gene Symbol
TMEM106B
Gene Synonym (2)
FLJ11273MGC33727
Gene Description
Transmembrane protein 106B
Chromosome
7
Position
12211270-12243367
Supporting publications (n)
2
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecificliverCell SpecificConjunctival goblet cellsSingle-Nuclei Brain SpecificpericyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (5)
  • Transporters
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Potential drug targets
  • Disease related genes
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence22

Ligand-Receptor Signaling (20)

20 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
extracellularextracellularOmniPath
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembrane_predictedtransmembraneOmniPath
transmembranetransmembraneTopDB
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
TMEM106BQ9NUM43PDBPDB:7u15PDB:7u17PDB:7x83PDB:7qwgPDB:8f9kPDB:9fnbPDB:8j7pPDB:7u14PDB:7sarPDB:7u12PDB:7qwlPDB:8x5hPDB:7sasPDB:7u11PDB:7qwmPDB:7u10PDB:7u16PDB:7x84PDB:8j7nPDB:8otdPDB:7u18PDB:7qvcPDB:7qvfPDB:7saqPDB:7tmcPDB:7u13PDB:8ote

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry23511977838716512
Sequence, Structure & Domains

Sequences

Length
274
Mass
31,127
Sequence
MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ

3D Structural Models

Turn
137..140
Helix
205..208; 209..214
Beta Strand
122..136; 141..153; 156..158; 160..171; 174..183; 184..187; 192..203; 216..220; 223..236; 239..252
3D Structure
Electron microscopy (27); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias
1..11; Low complexity
Region
1..20; Disordered
Protein Families
TMEM106 family
Sequence Similarities
Belongs to the TMEM106 family.
Clinical Relevance
Disease Involvement (4)
Amyotrophic lateral sclerosisDisease variantLeukodystrophyNeurodegeneration
Related Diseases (2)
Amyotrophic lateral sclerosisLeukodystrophy
Antibody
HPA058342
Interaction Protein (3)
ENSG00000134291ENSG00000170088ENSG00000204525
Interaction Count
3
Interaction Dataset (3)
intact_biogridbiogrid_opencellbiogrid_bioplex
Supporting Publications2
PMIDTitleRelated sentences
33905554Proteomic analysis of extracellular vesicles identified PI3K pathway as a potential therapeutic target for cabazitaxel-resistant prostate cancer.No related sentences available
41307968Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.No related sentences available