Protein detail
T106B
Transmembrane protein 106B
Entry name T106B | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Transmembrane protein 106B
Protein Class (6)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Disease related genes
Transmembrane
97..117; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FLJ11273MGC33727
Gene Description
Transmembrane protein 106B
Chromosome
7
Position
12211270-12243367
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization5
Tissue SpecificliverCell SpecificConjunctival goblet cellsSingle-Nuclei Brain SpecificpericyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway5
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Disease related genes
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence22
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
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Protein Complex Composition (1)
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TMEM106B | Q9NUM4 | 3 | PDB | PDB:7u15PDB:7u17PDB:7x83PDB:7qwgPDB:8f9kPDB:9fnbPDB:8j7pPDB:7u14PDB:7sarPDB:7u12PDB:7qwlPDB:8x5hPDB:7sasPDB:7u11PDB:7qwmPDB:7u10PDB:7u16PDB:7x84PDB:8j7nPDB:8otdPDB:7u18PDB:7qvcPDB:7qvfPDB:7saqPDB:7tmcPDB:7u13PDB:8ote |
Sequence, Structure & Domains11
Sequences
Length
274
Mass
31,127
Sequence
MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ
3D Structural Models
Turn
137..140
Helix
205..208; 209..214
Beta Strand
122..136; 141..153; 156..158; 160..171; 174..183; 184..187; 192..203; 216..220; 223..236; 239..252
3D Structure
Electron microscopy (27); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..11; Low complexity
Region
1..20; Disordered
Protein Families
TMEM106 family
Sequence Similarities
Belongs to the TMEM106 family.
Clinical Relevance5
Disease Involvement (4)
Amyotrophic lateral sclerosisDisease variantLeukodystrophyNeurodegeneration
Antibody
Interaction Protein (3)
ENSG00000134291ENSG00000170088ENSG00000204525
Interaction Count
3
Interaction Dataset (3)
intact_biogridbiogrid_opencellbiogrid_bioplex
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 33905554 | Proteomic analysis of extracellular vesicles identified PI3K pathway as a potential therapeutic target for cabazitaxel-resistant prostate cancer. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |