Protein detail
T106B
Transmembrane protein 106B
Protein symbol T106B | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Transmembrane protein 106B
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Disease related genes
Transmembrane
97..117; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ11273MGC33727
Gene Description
Transmembrane protein 106B
Chromosome
7
Position
12211270-12243367
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificliverCell SpecificConjunctival goblet cellsSingle-Nuclei Brain SpecificpericyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Disease related genes
Cellular Component
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TMEM106B | Q9NUM4 | 3 | PDB | PDB:7u15PDB:7u17PDB:7x83PDB:7qwgPDB:8f9kPDB:9fnbPDB:8j7pPDB:7u14PDB:7sarPDB:7u12PDB:7qwlPDB:8x5hPDB:7sasPDB:7u11PDB:7qwmPDB:7u10PDB:7u16PDB:7x84PDB:8j7nPDB:8otdPDB:7u18PDB:7qvcPDB:7qvfPDB:7saqPDB:7tmcPDB:7u13PDB:8ote |
Sequence, Structure & Domains
Sequences
Length
274
Mass
31,127
Sequence
MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ
3D Structural Models
Turn
137..140
Helix
205..208; 209..214
Beta Strand
122..136; 141..153; 156..158; 160..171; 174..183; 184..187; 192..203; 216..220; 223..236; 239..252
3D Structure
Electron microscopy (27); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..11; Low complexity
Region
1..20; Disordered
Protein Families
TMEM106 family
Sequence Similarities
Belongs to the TMEM106 family.
Clinical Relevance
Disease Involvement
Amyotrophic lateral sclerosisDisease variantLeukodystrophyNeurodegeneration
Antibody
Interaction Protein
ENSG00000134291ENSG00000170088ENSG00000204525
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_opencellbiogrid_bioplex