Protein detail
T106B
Transmembrane protein 106B
Entry name T106B | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Transmembrane protein 106B
Protein Class (6)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Disease related genes
Transmembrane
97..117; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FLJ11273MGC33727
Gene Description
Transmembrane protein 106B
Chromosome
7
Position
12211270-12243367
Supporting publications (n)
2
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecificliverCell SpecificConjunctival goblet cellsSingle-Nuclei Brain SpecificpericyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Disease related genes
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence22
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath | |||||
| transmembrane | transmembrane_predicted | Phobius | |||||
| transmembrane_phobius | transmembrane_predicted | Almen2009 | |||||
| transmembrane_sosui | transmembrane_predicted | Almen2009 | |||||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 |
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Protein Complex Composition (1)
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TMEM106B | Q9NUM4 | 3 | PDB | PDB:7u15PDB:7u17PDB:7x83PDB:7qwgPDB:8f9kPDB:9fnbPDB:8j7pPDB:7u14PDB:7sarPDB:7u12PDB:7qwlPDB:8x5hPDB:7sasPDB:7u11PDB:7qwmPDB:7u10PDB:7u16PDB:7x84PDB:8j7nPDB:8otdPDB:7u18PDB:7qvcPDB:7qvfPDB:7saqPDB:7tmcPDB:7u13PDB:8ote |
Sequence, Structure & Domains
Sequences
Length
274
Mass
31,127
Sequence
MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ
3D Structural Models
Turn
137..140
Helix
205..208; 209..214
Beta Strand
122..136; 141..153; 156..158; 160..171; 174..183; 184..187; 192..203; 216..220; 223..236; 239..252
3D Structure
Electron microscopy (27); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..11; Low complexity
Region
1..20; Disordered
Protein Families
TMEM106 family
Sequence Similarities
Belongs to the TMEM106 family.
Clinical Relevance
Disease Involvement (4)
Amyotrophic lateral sclerosisDisease variantLeukodystrophyNeurodegeneration
Related Diseases (2)
Antibody
Interaction Protein (3)
ENSG00000134291ENSG00000170088ENSG00000204525
Interaction Count
3
Interaction Dataset (3)
intact_biogridbiogrid_opencellbiogrid_bioplex
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 33905554 | Proteomic analysis of extracellular vesicles identified PI3K pathway as a potential therapeutic target for cabazitaxel-resistant prostate cancer. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |