Protein detail

ANO10

Anoctamin-10 (Transmembrane protein 16K)

Entry name ANO10	UniProt ID Q9NW15	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count 8	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Anoctamin-10 (Transmembrane protein 16K)

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Transmembrane

208..228; Helical; 241..261; Helical; 317..337; Helical; 353..373; Helical; 401..421; Helical; 501..521; Helical; 554..574; Helical; 591..611; Helical

Transmembrane Count

Ensembl

ENSG00000160746

Entrez Gene Symbol

ANO10

Gene Synonym (4)

FLJ10375MGC47890SCAR10TMEM16K

Gene Description

Anoctamin 10

Chromosome

Position

43354859-43691594

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization1

Function & Pathway5

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Potential drug targets
Transporters:Transporter channels and pores
Disease related genes

Cellular Component (3)

Molecular Function (3)

Reactome (9)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence13

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	OPM	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	6	35294531 33204424 39766158 36398564 39940923 29148239

Sequence, Structure & Domains11

Sequences

Length

660

Mass

76,329

Sequence

MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9NW15-1; Sequence=Displayed; Name=2; IsoId=Q9NW15-2; Sequence=VSP_026033; Name=3; IsoId=Q9NW15-3; Sequence=VSP_038212; Name=4; IsoId=Q9NW15-4; Sequence=VSP_038211; Name=5; IsoId=Q9NW15-5; Sequence=VSP_045885

Alternative Sequence

47..158; GAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLL -> V (in isoform 4); 47..112; Missing (in isoform 3); 198..387; Missing (in isoform 2); 600..660; HALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT -> AASCKLVSLPRYSWSTNSVPGTVIGPGV (in isoform 5)

3D Structural Models

Turn

235..237; 274..276; 512..514

Helix

29..40; 43..45; 60..62; 63..66; 76..86; 105..107; 121..133; 157..163; 176..186; 197..204; 206..234; 240..272; 279..281; 307..316; 318..348; 355..358; 361..387; 393..421; 426..437; 439..448; 450..468; 477..487; 495..511; 518..539; 555..576; 578..581; 588..612; 618..638

Beta Strand

19..23; 51..54; 69..73; 89..92; 97..99; 136..139; 141..143; 146..150; 166..172; 291..294; 296..298; 301..304; 352..354; 584..586

3D Structure

Electron microscopy (3); X-ray crystallography (2)

Domain & Motif Annotations

Protein Families

Anoctamin family

Sequence Similarities

Belongs to the anoctamin family.

Clinical Relevance2

Disease Involvement (2)

Disease variantNeurodegeneration

Antibody (2)

HPA016624 HPA051569

Supporting Publications6

PMID	Title	Abstract
30178811	Effect of exercise on the plasma vesicular proteome: a methodological study comparing acoustic trapping and centrifugation.	No abstract available
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
38396626	Protein Profiling of Placental Extracellular Vesicles in Gestational Diabetes Mellitus.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available