Protein detail
ANO10
Anoctamin-10 (Transmembrane protein 16K)
Entry name ANO10 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count 8 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Anoctamin-10 (Transmembrane protein 16K)
Protein Class (6)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
Transmembrane
208..228; Helical; 241..261; Helical; 317..337; Helical; 353..373; Helical; 401..421; Helical; 501..521; Helical; 554..574; Helical; 591..611; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
FLJ10375MGC47890SCAR10TMEM16K
Gene Description
Anoctamin 10
Chromosome
3
Position
43354859-43691594
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization1
Function & Pathway5
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component (3)
Molecular Function (3)
Reactome (9)
- R-hsa-9733458 induction of cell cell fusion
- R-hsa-5663205 infectious disease
- R-hsa-983712 ion channel transport
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-2672351 stimuli sensing channels
- R-hsa-382551 transport of small molecules
- R-hsa-9824446 viral infection pathways
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence13
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Sequence, Structure & Domains11
Sequences
Length
660
Mass
76,329
Sequence
MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9NW15-1; Sequence=Displayed; Name=2; IsoId=Q9NW15-2; Sequence=VSP_026033; Name=3; IsoId=Q9NW15-3; Sequence=VSP_038212; Name=4; IsoId=Q9NW15-4; Sequence=VSP_038211; Name=5; IsoId=Q9NW15-5; Sequence=VSP_045885
Alternative Sequence
47..158; GAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLL -> V (in isoform 4); 47..112; Missing (in isoform 3); 198..387; Missing (in isoform 2); 600..660; HALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT -> AASCKLVSLPRYSWSTNSVPGTVIGPGV (in isoform 5)
3D Structural Models
Turn
235..237; 274..276; 512..514
Helix
29..40; 43..45; 60..62; 63..66; 76..86; 105..107; 121..133; 157..163; 176..186; 197..204; 206..234; 240..272; 279..281; 307..316; 318..348; 355..358; 361..387; 393..421; 426..437; 439..448; 450..468; 477..487; 495..511; 518..539; 555..576; 578..581; 588..612; 618..638
Beta Strand
19..23; 51..54; 69..73; 89..92; 97..99; 136..139; 141..143; 146..150; 166..172; 291..294; 296..298; 301..304; 352..354; 584..586
3D Structure
Electron microscopy (3); X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
Anoctamin family
Sequence Similarities
Belongs to the anoctamin family.
Clinical Relevance2
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 30178811 | Effect of exercise on the plasma vesicular proteome: a methodological study comparing acoustic trapping and centrifugation. | No abstract available |
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 38396626 | Protein Profiling of Placental Extracellular Vesicles in Gestational Diabetes Mellitus. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |