Protein detail

DCA16

DDB1- and CUL4-associated factor 16

Entry name DCA16	UniProt ID Q9NXF7	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

DDB1- and CUL4-associated factor 16

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000163257

Entrez Gene Symbol

DCAF16

Gene Synonym (2)

C4orf30FLJ20280

Gene Description

DDB1 and CUL4 associated factor 16

Chromosome

Position

17800655-17810758

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Reactome (2)

Mediation Categories

Metabolism mediation

Relations & Evidence18

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (13)

13 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CRL4-DCAF16 E3 ubiquitin ligase complexCUL4A variant	CUL4A DCAF16 DDB1 RBX1	P62877 Q13619 Q16531 Q9NXF7	1:1:1:1	ComplexPortal	intact:EBI-9015660	14755292 34720086 33636084 16949367
CRL4-DCAF16 E3 ubiquitin ligase complexCUL4B variant	CUL4B DCAF16 DDB1 RBX1	P62877 Q13620 Q16531 Q9NXF7	1:1:1:1	ComplexPortal	intact:EBI-9015948	14755292 34720086 33636084 16949367
CUL4 RING ubiquitin ligase complex	CUL4A DCAF10 DCAF11 DCAF12 DCAF13 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCAF7 DCAF8 DDB1 FBXW5	P61962 Q13619 Q16531 Q58WW2 Q5H9S7 Q5QP82 Q5T6F0 Q5TAQ9 Q8TEB1 Q8WV16 Q969U6 Q96JK2 Q9NV06 Q9NXF7	1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC791	18381890 16949367
	BRD4 DCAF16 DDA1 DDB1	O60885 Q16531 Q9BW61 Q9NXF7	1:1:1:1	PDB	PDB:8g46
	BRD4 DCAF16 DDB1	O60885 Q16531 Q9NXF7	1:1:1	PDB	PDB:8ov6
	ANGEL1 ANKRD50 DCAF16 KDM4A KDM4B NOC4L NOP14 ZNF414	O75164 O94953 P78316 Q96IQ9 Q9BVI4 Q9NXF7 Q9ULJ7 Q9UNK9	0:0:0:0:0:0:0:0	hu.MAP2
	BRWD1 DCAF10 DCAF16 DCAF6 DDB1 TOR1AIP2	Q16531 Q58WW2 Q5QP82 Q8NFQ8 Q9NSI6 Q9NXF7	0:0:0:0:0:0	hu.MAP
	BRWD1 DCAF10 DCAF16 DCAF6 DDB1 TOR1AIP2	Q16531 Q58WW2 Q5QP82 Q9H496 Q9NSI6 Q9NXF7	0:0:0:0:0:0	hu.MAP
	DCAF16 DDB1 PHIP TOR1AIP2	Q16531 Q8NFQ8 Q8WWQ0 Q9NXF7	0:0:0:0	hu.MAP2
	DCAF16 DDB1 TOR1AIP2	Q16531 Q8NFQ8 Q9NXF7	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	35399949

Sequence, Structure & Domains9

Sequences

Length

216

Mass

24,193

Sequence

MGPRNPSPDHLSESESEEEENISYLNESSGEEWDSSEEEDSMVPNLSPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLTSPSRLSRDHATLNGALQFATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVNKLLTASL

3D Structural Models

Turn

101..103; 190..192

Helix

48..60; 74..77; 88..94; 116..119; 131..138; 143..157; 179..186; 201..215

Beta Strand

64..67; 97..100

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

29..41; Acidic residues

Region

1..42; Disordered

Clinical Relevance4

Antibody

HPA042487

Interaction Protein (2)

ENSG00000167986ENSG00000186767

Interaction Count

Interaction Dataset (2)

biogrid_opencellbiogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available