Protein detail

DCA16

DDB1- and CUL4-associated factor 16

Entry name DCA16	UniProt ID Q9NXF7	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

DDB1- and CUL4-associated factor 16

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000163257

Entrez Gene Symbol

DCAF16

Gene Synonym (2)

C4orf30FLJ20280

Gene Description

DDB1 and CUL4 associated factor 16

Chromosome

Position

17800655-17810758

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Reactome (2)

Mediation Categories

Metabolism mediation

Relations & Evidence18

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (13)

13 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
DCAF16 DDB1 PHIP TOR1AIP2	Q16531 Q8WWQ0 Q9H496 Q9NXF7	0:0:0:0	hu.MAP2
DCAF1 DCAF16 DDA1 DDB1	Q16531 Q9BW61 Q9NXF7 Q9Y4B6	0:0:0:0	hu.MAP2
DCAF16 DDB1 TOR1AIP2	Q16531 Q9H496 Q9NXF7	0:0:0	hu.MAP

Page 2 of 2Previous

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	35399949

Sequence, Structure & Domains9

Sequences

Length

216

Mass

24,193

Sequence

MGPRNPSPDHLSESESEEEENISYLNESSGEEWDSSEEEDSMVPNLSPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLTSPSRLSRDHATLNGALQFATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVNKLLTASL

3D Structural Models

Turn

101..103; 190..192

Helix

48..60; 74..77; 88..94; 116..119; 131..138; 143..157; 179..186; 201..215

Beta Strand

64..67; 97..100

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

29..41; Acidic residues

Region

1..42; Disordered

Clinical Relevance4

Antibody

HPA042487

Interaction Protein (2)

ENSG00000167986ENSG00000186767

Interaction Count

Interaction Dataset (2)

biogrid_opencellbiogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available