Protein detail

CLDN1

Claudin domain-containing protein 1 (Claudin-25) (Membrane protein GENX-3745)

Protein symbol CLDN1	UniProt ID Q9NY35	EVMP score 0.25
Frequency 1	Transmembrane count 4	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Claudin domain-containing protein 1 (Claudin-25) (Membrane protein GENX-3745)

Protein Class

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

5..25; Helical; 141..161; Helical; 175..195; Helical; 216..236; Helical

Transmembrane Count

Ensembl

ENSG00000080822

Entrez Gene Symbol

CLDND1

Gene Synonym

C3orf4Z38

Gene Description

Claudin domain containing 1

Chromosome

Position

98497912-98523066

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificbrainCell SpecificOligodendrocytesSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Page 1 of 2Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CLDND1 GOLGA7 MAN1A1 MAN1A2 ZDHHC8	O60476 P33908 Q7Z5G4 Q9NY35 Q9ULC8	0:0:0:0:0	hu.MAPhu.MAP2
	CLDND1 GOLGA7 MAN1A1 ZDHHC8	P33908 Q7Z5G4 Q9NY35 Q9ULC8	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains

Sequences

Length

253

Mass

28,603

Sequence

MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NY35-1; Sequence=Displayed; Name=2; IsoId=Q9NY35-2; Sequence=VSP_013156, VSP_013157; Name=3; IsoId=Q9NY35-3; Sequence=VSP_046865

Alternative Sequence

1..97; MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERT -> MG (in isoform 3); 181..184; GLCT -> DTML (in isoform 2); 185..253; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (CC)

The C-terminal region is required for localization to tight junctions which occurs in a TJP1/ZO1-independent manner.

Protein Families

PMP-22/EMP/MP20 family

Sequence Similarities

Belongs to the PMP-22/EMP/MP20 family.

Clinical Relevance

Antibody

HPA029841

Interaction Protein

ENSG00000147533

Interaction Count

Interaction Dataset

biogrid_opencell