Protein detail

CLDN1

Claudin domain-containing protein 1 (Claudin-25) (Membrane protein GENX-3745)

Entry name CLDN1	UniProt ID Q9NY35	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 4	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Claudin domain-containing protein 1 (Claudin-25) (Membrane protein GENX-3745)

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

5..25; Helical; 141..161; Helical; 175..195; Helical; 216..236; Helical

Transmembrane Count

Ensembl

ENSG00000080822

Entrez Gene Symbol

CLDND1

Gene Synonym (2)

C3orf4Z38

Gene Description

Claudin domain containing 1

Chromosome

Position

98497912-98523066

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificOligodendrocytesSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway5

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence18

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Page 2 of 2Previous

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CLDND1 GOLGA7 MAN1A1 MAN1A2 ZDHHC8	O60476 P33908 Q7Z5G4 Q9NY35 Q9ULC8	0:0:0:0:0	hu.MAPhu.MAP2
	CLDND1 GOLGA7 MAN1A1 ZDHHC8	P33908 Q7Z5G4 Q9NY35 Q9ULC8	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains8

Sequences

Length

253

Mass

28,603

Sequence

MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERTESFDVVTKCVSFTLTEQFMEKFVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLELPDNVSGEFGWSFCLACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NY35-1; Sequence=Displayed; Name=2; IsoId=Q9NY35-2; Sequence=VSP_013156, VSP_013157; Name=3; IsoId=Q9NY35-3; Sequence=VSP_046865

Alternative Sequence

1..97; MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPVQENSSDLNKSIWDEFISDEADEKTYNDALFRYNGTVGLWRRCITIPKNMHWYSPPERT -> MG (in isoform 3); 181..184; GLCT -> DTML (in isoform 2); 185..253; Missing (in isoform 2)

Domain & Motif Annotations

Domain (CC)

The C-terminal region is required for localization to tight junctions which occurs in a TJP1/ZO1-independent manner.

Protein Families

PMP-22/EMP/MP20 family

Sequence Similarities

Belongs to the PMP-22/EMP/MP20 family.

Clinical Relevance4

Antibody

HPA029841

Interaction Protein

ENSG00000147533

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available