Protein detail

SCN3B

Sodium channel regulatory subunit beta-3

Entry name SCN3B	UniProt ID Q9NY72	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Sodium channel regulatory subunit beta-3

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
FDA approved drug targets:Small molecule drugs

Transmembrane

157..178; Helical

Transmembrane Count

Ensembl

ENSG00000166257

Entrez Gene Symbol

SCN3B

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function (3)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
FDA approved drug targets:Small molecule drugs

Cellular Component (4)

Molecular Function (5)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Reactome (6)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence37

Ligand-Receptor Signaling (33)

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
voltage_gated_sodium	ion_channel	HGNC	No	Yes	No	Yes	No
ion_channel	ion_channel	HGNC	No	Yes	No	Yes	No
beta_sodium	ion_channel	Almen2009	No	Yes	No	Yes	No
transporter	transporter	OmniPath	No	Yes	No	Yes	No
ion_channel	ion_channel	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ERG28 HSDL1 MTCL3 PEX10 SCN3B SLC38A3 TARBP1	O60683 Q13395 Q3SXM5 Q5TF21 Q99624 Q9NY72 Q9UKR5	0:0:0:0:0:0:0	hu.MAP2
DHRS7 MTCL3 PEX10 SCN3B SLC38A3	O60683 Q5TF21 Q99624 Q9NY72 Q9Y394	0:0:0:0:0	hu.MAP2
SCN3B	Q9NY72	3	PDB	PDB:4l1d

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	R Sequencing	2	41307968 38207106

Sequence, Structure & Domains10

Sequences

Length

215

Mass

24,702

Sequence

MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE

3D Structural Models

Turn

87..90

Helix

112..114; 153..185

Beta Strand

34..36; 41..43; 57..65; 66..68; 72..82; 91..94; 100..102; 105..107; 116..125; 135..145

3D Structure

Electron microscopy (2); X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

32..154; Ig-like C2-type

Protein Families

Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family

Sequence Similarities

Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.

Clinical Relevance4

Drugs

ZONISAMIDE

Interaction Protein (3)

ENSG00000107819ENSG00000133935ENSG00000173409

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available