Protein detail
SCN3B
Sodium channel regulatory subunit beta-3
Protein symbol SCN3B | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Sodium channel regulatory subunit beta-3
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
157..178; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| voltage_gated_sodium | ion_channel | HGNC | No | Yes | No | Yes | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | Yes | No |
| beta_sodium | ion_channel | Almen2009 | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
Sequence, Structure & Domains
Sequences
Length
215
Mass
24,702
Sequence
MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
3D Structural Models
Turn
87..90
Helix
112..114; 153..185
Beta Strand
34..36; 41..43; 57..65; 66..68; 72..82; 91..94; 100..102; 105..107; 116..125; 135..145
3D Structure
Electron microscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
32..154; Ig-like C2-type
Protein Families
Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family
Sequence Similarities
Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
Clinical Relevance
Drugs
Interaction Protein
ENSG00000107819ENSG00000133935ENSG00000173409
Interaction Count
3
Interaction Dataset
intact_biogrid