Protein detail
SCN3B
Sodium channel regulatory subunit beta-3
Entry name SCN3B | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Sodium channel regulatory subunit beta-3
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
157..178; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.40
Fluorescence & Localization
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component (4)
Molecular Function (5)
Biological Process (3)
Reactome (6)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence37
Ligand-Receptor Signaling (33)
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | LOCATE | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes | ||||
| transmembrane | transmembrane_predicted | Phobius | Yes |
Protein Complex Composition (3)
3 records.
Sequence, Structure & Domains
Sequences
Length
215
Mass
24,702
Sequence
MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
3D Structural Models
Turn
87..90
Helix
112..114; 153..185
Beta Strand
34..36; 41..43; 57..65; 66..68; 72..82; 91..94; 100..102; 105..107; 116..125; 135..145
3D Structure
Electron microscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
32..154; Ig-like C2-type
Protein Families
Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family
Sequence Similarities
Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
Clinical Relevance
Drugs
Interaction Protein (3)
ENSG00000107819ENSG00000133935ENSG00000173409
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |