Protein detail
NINJ2
Ninjurin-2 (Nerve injury-induced protein 2)
Protein symbol NINJ2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 2 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ninjurin-2 (Nerve injury-induced protein 2)
Transmembrane
61..92; Helical; Name=Helix alpha3; 97..126; Helical; Name=Helix alpha4
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | No | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Western blotting | 1 | 40098346 |
Sequence, Structure & Domains
Sequences
Length
142
Mass
15,680
Sequence
MESARENIDLQPGSSDPRSQPINLNHYATKKSVAESMLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFGAHKTGFLAARASRNPL
3D Structural Models
Helix
27..36; 40..56; 63..93; 99..125
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
12..21; Polar residues
Domain (CC)
Composed of 4 alpha helices: 2 hydrophobic transmembrane regions (alpha3 and alpha4) and 2 alpha helices (alpha1 and alpha2) (PubMed:39667936). Alpha1 and alpha2 feature one hydrophobic side and a hydrophilic side (PubMed:39667936). In contrast to NINJ1, does not disrupt membrane integrity (PubMed:38614101, PubMed:39667936). NINJ2 filaments are curved toward the intracellular space due to cholesterol-binding, preventing circularization and ability to mediate plasma membrane rupture (PubMed:39667936).
Region
1..21; Disordered; 25..37; Helix alpha1; 38..57; Helix alpha2
Protein Families
Ninjurin family
Sequence Similarities
Belongs to the ninjurin family.