Protein detail

PD1L1

Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)

Entry name PD1L1	UniProt ID Q9NZQ7	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsPredicted membrane proteinsPredicted secreted proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)

Protein Class (7)

Cancer-related genesCD markersDisease related genesFDA approved drug targetsPredicted membrane proteinsPredicted secreted proteinsTransporters

Protein Function (6)

CD markers
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport
Cancer-related genes
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

239..259; Helical

Transmembrane Count

Ensembl

ENSG00000120217

Entrez Gene Symbol

CD274

Gene Synonym (6)

B7-HB7-H1B7H1PD-L1PDCD1LG1PDL1

Gene Description

CD274 molecule

Chromosome

Position

5450503-5470566

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (6)

CD markers
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport
Cancer-related genes
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component (7)

Molecular Function (3)

KEGG (2)

Reactome (14)

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Canonical Pathways (3)

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence76

Enzyme-Mediated Modification (10)

10 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
CD274	PRKAA1	Q13131	S	283	phosphorylation	PhosphoSite
CD274	PRKAA1	Q13131	S	195	phosphorylation	PhosphoSite
CD274	JAK1	P23458	Y	112	phosphorylation	PhosphoSite
CD274	GSK3B	P49841	S	184	phosphorylation	PhosphoSite
CD274	GSK3B	P49841	T	180	phosphorylation	PhosphoSite
CD274	PRKAA2	P54646	S	283	phosphorylation	PhosphoSite
CD274	GSK3A	P49840	S	279	phosphorylation	PhosphoSite
CD274	GSK3A	P49840	S	283	phosphorylation	PhosphoSite
CD274	NEK2	P51955	T	194	phosphorylation	PhosphoSite
CD274	NEK2	P51955	T	210	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (46)

46 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
b7_family	cell_surface_ligand	HGNC	Yes	No	Yes	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	Yes	Yes	No
transmembrane	transmembrane	TopDB	No	No	Yes	Yes	No

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Regulatory Interaction Network (19)

19 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CHIP	Q9UNE7	PD1L1	Q9NZQ7	Yes	No	Yes	SIGNOR	SIGNOR:28813410
ARI1	Q9Y4X5	PD1L1	Q9NZQ7	Yes	No	Yes	SIGNOR	SIGNOR:33879767
SPOP	O43791	PD1L1	Q9NZQ7	Yes	No	Yes	SIGNOR	SIGNOR:29160310
PD1L1	Q9NZQ7	PDCD1	Q15116	Yes	Yes	No	iTALKKEGG-MEDICUSICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17CellChatDBscConnectHPRDWojtowicz2020IntActWangCellPhoneDBBioGRIDCellinkerGuide2PharmaCellTalkDBconnectomeDB2020LRdb	InnateDB:18841514 InnateDB:11015443 IntAct:20587542 HINT:26602187 CellChatDB:23954143 BioGRID:36657039 HINT:36657039 IntAct:23417675 IntAct:21982860 HINT:31802034 LRdb:12889478 HPRD:12719480 Cellinker:26681673 HINT:23417675 Lit-BM-17:21982860 Cellinker:31757674 HINT:11015443 SIGNOR:11015443 HINT:12893276 Cellinker:23954143 HINT:21982860 InnateDB:12893276 HINT:27618663 DIP:26602187 HPRD:12893276 connectomeDB2020:23954143 HINT:20587542 ICELLNET:23954143 InnateDB:21422170
	COMPLEX:P63208_Q13616_Q9Y297	PD1L1	Q9NZQ7	Yes	No	Yes	SIGNOR	SIGNOR:27572267
CKLF4	Q8IZR5	PD1L1	Q9NZQ7	Yes	Yes	No	SIGNOR	SIGNOR:28813410
SGMR1	Q99720	PD1L1	Q9NZQ7	Yes	Yes	No	SIGNOR	SIGNOR:29117944
AAPK1	Q13131	PD1L1	Q9NZQ7	Yes	No	No	Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:33909988 ProtMapper:30118680 PhosphoSite:30118680 ProtMapper:34088360 ProtMapper:32467592 PhosphoSite:33879767 ProtMapper:33114576
JAK1	P23458	PD1L1	Q9NZQ7	Yes	No	No	Sparser_ProtMapperProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:31668929 ProtMapper:32620165 ProtMapper:33312953 PhosphoSite:31305264 ProtMapper:33298250 ProtMapper:34088360 ProtMapper:34315872 ProtMapper:32802517 ProtMapper:32377193

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	0

Sequence, Structure & Domains12

Sequences

Length

290

Mass

33,275

Sequence

MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PD-L1I; IsoId=Q9NZQ7-1; Sequence=Displayed; Name=2; Synonyms=PD-L1II; IsoId=Q9NZQ7-2; Sequence=VSP_013735; Name=3; IsoId=Q9NZQ7-3; Sequence=VSP_013736, VSP_013737; Name=4; Synonyms=secPD-L1; IsoId=Q9NZQ7-4; Sequence=VSP_061953

Alternative Sequence

19..132; Missing (in isoform 2); 178; K -> D (in isoform 3); 179..290; Missing (in isoform 3); 228..289; ELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEE -> GNILNVSIKICLTLSPS (in isoform 4)

3D Structural Models

Turn

82..84; 146..149; 214..217

Helix

50..52; 74..76; 79..81; 89..94; 106..108; 237..265

Beta Strand

26..31; 36..41; 45..47; 54..59; 62..68; 71..73; 85..87; 96..103; 110..131; 138..145; 150..161; 164..169; 177..183; 185..187; 191..200; 206..213; 218..225; 268..271

3D Structure

NMR spectroscopy (2); X-ray crystallography (63)

Domain & Motif Annotations

Domain (FT)

19..127; Ig-like V-type; 133..225; Ig-like C2-type

Protein Families (2)

Immunoglobulin superfamily
BTN/MOG family

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Clinical Relevance7

Disease Involvement (2)

Cancer-related genesFDA approved drug targets

Drug Targets (2)

FDA approved drug targetsClinical trial target

Drugs (85)

ANTI-PD-L1 MONOCLONAL ANTIBODY MDX-1105 ZALIFRELIMAB SOCAZOLIMAB AVELUMAB ATEZOLIZUMAB NULL ENVAFOLIMAB NIRAPARIB ANTI-PD-L1/CD27 BISPECIFIC ANTIBODY CDX-527 CARBOPLATIN TORIPALIMAB-TPZI DABRAFENIB TISLELIZUMAB CA-170 RITUXIMAB NIVOLUMAB INCB086550 BINTRAFUSP ALFA CEMIPLIMAB-RWLC VACTOSERTIB NOFAZINLIMAB ENGINEERED TOXIN BODY TARGETING PD-L1 MT-6402 RILVEGOSTOMIG PEMETREXED DISODIUM TRABECTEDIN IPILIMUMAB BETIFISOLIMAB PEMBROLIZUMAB DURVALUMAB INCB-086550 NAB-PACLITAXEL DOXORUBICIN HYDROCHLORIDE CADONILIMAB SUGEMALIMAB PEPINEMAB ERFONRILIMAB PUCOTENLIMAB BMS-936559 CETRELIMAB ADO-TRASTUZUMAB EMTANSINE PEGILODECAKIN PIMIVALIMAB TRAMETINIB DIMETHYL SULFOXIDE SERINE/THREONINE KINASE INHIBITOR CBP501 SULFATINIB ANTI-PD-L1 MONOCLONAL ANTIBODY FAZ053 IMATINIB BALSTILIMAB DOXORUBICIN LIPOSOME IRINOTECAN HYDROCHLORIDE PD-L1/IDO PEPTIDE VACCINE IO102-103 PACMILIMAB ANTI-LAG-3/PD-L1 BISPECIFIC ANTIBODY FS118 CISPLATIN MAGROLIMAB ONCOLYTIC TYPE 2 HERPES SIMPLEX VIRUS EXPRESSING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR OH2 SHR-1316 PIDILIZUMAB JQ1 ERIBULIN MESYLATE ANLOTINIB ARC FUSION PROTEIN SL-279252 ANTI-PD-L1/CD137 BISPECIFIC ANTIBODY MCLA-145 APL-501 TREMELIMUMAB AXITINIB BEVACIZUMAB-AWWB OXALIPLATIN TIRAGOLUMAB CAPECITABINE SINTILIMAB ACASUNLIMAB LODAPOLIMAB GEMCITABINE PACLITAXEL LMB-100 ANTI-CD47/ANTI-PD-L1 BISPECIFIC ANTIBODY PF-07257876 SASANLIMAB RETIFANLIMAB COSIBELIMAB DANBURSTOTUG FLUOROURACIL RIVOCERANIB SPARTALIZUMAB CAMRELIZUMAB

Antibody (3)

HPA003528 CAB076385 CAB080537

Interaction Protein (2)

ENSG00000091317ENSG00000188389

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available