Protein detail

KLRF1

Killer cell lectin-like receptor subfamily F member 1 (Lectin-like receptor F1) (Activating coreceptor NKp80) (C-type lectin domain family 5 member C)

Entry name KLRF1	UniProt ID Q9NZS2	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information7

Protein Names

Killer cell lectin-like receptor subfamily F member 1 (Lectin-like receptor F1) (Activating coreceptor NKp80) (C-type lectin domain family 5 member C)

Transmembrane

39..59; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000150045

Entrez Gene Symbol

KLRF1

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificKupffer cellsSingle-Nuclei Brain Specificleukocyte

Function & Pathway5

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Reactome (2)

Mediation Categories

Immune mediation

Relations & Evidence50

Ligand-Receptor Signaling (48)

48 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
c_lectinn_containing_scavenger_scavenger	receptor	HPMR	No	Yes	No	Yes	No
class_e	receptor	Surfaceome	No	Yes	No	Yes	No
scar	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	KLRF1	Q9NZS2	10	PDB	PDB:8qmd

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	R Sequencing	2	38731868 37922300

Sequence, Structure & Domains7

Sequences

Length

231

Mass

26,563

Sequence

MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYKILLGISGTVNGILTLTLISLILLVSQGVLLKCQKGSCSNATQYEDTGDLKVNNGTRRNISNKDLCASRSADQTVLCQSEWLKYQGKCYWFSNEMKSWSDSYVYCLERKSHLLIIHDQLEMAFIQKNLRQLNYVWIGLNFTSLKMTWTWVDGSPIDSKIFFIKGPAKENSCAAIKESKIFSETCSSVFKWICQY

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NZS2-1; Sequence=Displayed; Name=2; Synonyms=KLRF1-s1; IsoId=Q9NZS2-2; Sequence=VSP_010391; Name=3; Synonyms=KLRF1-s3; IsoId=Q9NZS2-3; Sequence=VSP_010390, VSP_010392; Name=4; Synonyms=KLRF1-s2; IsoId=Q9NZS2-4; Sequence=VSP_010393, VSP_010394

Alternative Sequence

62..78; VSQGVLLKCQKGSCSNA -> GFYTEKPKTIKLRMDWA (in isoform 4); 62..64; VSQ -> DSS (in isoform 3); 63..112; Missing (in isoform 2); 65..231; Missing (in isoform 3); 79..231; Missing (in isoform 4)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

121..230; C-type lectin

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available