Protein detail
PK2L1
Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1)
Protein symbol PK2L1 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 6 | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
Basic Information
Protein Names
Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
104..124; Helical; 357..376; Helical; 385..405; Helical; 434..454; Helical; 480..499; Helical; 537..557; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
PCLPKD2LPKDLTRPP3
Gene Description
Polycystin 2 like 1, transient receptor potential cation channel
Chromosome
10
Position
100288149-100330264
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
- GO:0005783 endoplasmic reticulum
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0031410 cytoplasmic vesicle
- GO:0034704 calcium channel complex
- GO:0043231 intracellular membrane-bounded organelle
- GO:0043235 receptor complex
- GO:0060170 ciliary membrane
- GO:0097730 non-motile cilium
Molecular Function
- GO:0005227 calcium-activated cation channel activity
- GO:0005261 monoatomic cation channel activity
- GO:0005262 calcium channel activity
- GO:0005272 sodium channel activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008092 cytoskeletal protein binding
- GO:0008324 monoatomic cation transmembrane transporter activity
- GO:0015269 calcium-activated potassium channel activity
- GO:0033040 sour taste receptor activity
- GO:0042802 identical protein binding
- GO:0044325 transmembrane transporter binding
- GO:0051371 muscle alpha-actinin binding
- GO:0051393 alpha-actinin binding
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PKD2L1 | PRKACA | P17612 | S | 685 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PKD2L1 | PRKACA | P17612 | S | 682 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PKD2L1 | PRKACA | P17612 | S | 686 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transient_receptor_potential_cation | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| transient_receptor_potential_cation | ion_channel | Almen2009 | No | Yes | No | No | No |
| voltage_gated | ion_channel | Almen2009 | No | Yes | No | No | No |
| voltage_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC2A | Q9UQM7 | PK2L1 | Q9P0L9 | Yes | No | Yes | SIGNOR | SIGNOR:37193065 |
| KAPCA | P17612 | PK2L1 | Q9P0L9 | Yes | Yes | No | PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:29230552SIGNOR:29230552 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | NA | 0 |
Sequence, Structure & Domains
Sequences
Length
805
Mass
91,982
Sequence
MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQETAYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETVLEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEVPYKREEEALEERRLSRGEIPTLQRS
Alternative Products
Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9P0L9-1; Sequence=Displayed; Name=2; Synonyms=PKDLdel15, PCL-TS, Testis isoform; IsoId=Q9P0L9-2; Sequence=VSP_004730, VSP_004731; Name=3; Synonyms=PKDLdel5; IsoId=Q9P0L9-3; Sequence=VSP_004729; Name=4; Synonyms=PKDLdel456; IsoId=Q9P0L9-4; Sequence=VSP_004728; Name=5; Synonyms=PCL-LV, Liver isoform; IsoId=Q9P0L9-5; Sequence=VSP_053718
Alternative Sequence
225..344; Missing (in isoform 4); 245..319; Missing (in isoform 3); 638..666; Missing (in isoform 5); 751..760; KEQAIWKHPQ -> RFPIKEKRKP (in isoform 2); 761..805; Missing (in isoform 2)
3D Structural Models
Turn
102..104; 119..121; 164..169; 310..313; 526..532
Helix
105..118; 127..137; 148..150; 157..160; 250..253; 278..290; 356..375; 385..419; 429..451; 452..454; 482..498; 511..521; 537..559; 704..731; 734..741
Beta Strand
183..185; 188..194; 202..205; 207..210; 229..232; 238..240; 243..246; 261..264; 298..309; 314..323; 333..339; 499..502; 504..506; 534..536
3D Structure
Electron microscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
780..796; Basic and acidic residues
Coiled Coil
650..686; 700..740
Domain (CC)
The EF-hand domain is not required for channel activation (PubMed:11959145).; DOMAIN: Interaction of the cytoplasmic N- and C-terminal domains is important for the non-selective cation channel activity.
Domain (FT)
633..668; EF-hand
Region
1..59; Disordered; 704..763; Required for homooligomerization; 759..805; Disordered
Protein Families
Polycystin family
Sequence Similarities
Belongs to the polycystin family.