Protein detail

PK2L1

Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1)

Entry name PK2L1	UniProt ID Q9P0L9	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 6	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1)

Protein Class (5)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels

Protein Function (3)

Voltage-gated ion channels:Transient Receptor Potential Channels
Transporters:Transporter channels and pores
Predicted intracellular proteins

Transmembrane

104..124; Helical; 357..376; Helical; 385..405; Helical; 434..454; Helical; 480..499; Helical; 537..557; Helical

Transmembrane Count

Ensembl

ENSG00000107593

Entrez Gene Symbol

PKD2L1

Gene Synonym (4)

PCLPKD2LPKDLTRPP3

Gene Description

Polycystin 2 like 1, transient receptor potential cation channel

Chromosome

Position

100288149-100330264

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway6

Protein Function (3)

Voltage-gated ion channels:Transient Receptor Potential Channels
Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component (12)

Page 1 of 2

Molecular Function (14)

Page 1 of 2

Biological Process (3)

KEGG

hsa04742 Taste transduction

Mediation Categories

Fusion and delivery mediation

Relations & Evidence39

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
PKD2L1	PRKACA	P17612	S	685	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
PKD2L1	PRKACA	P17612	S	682	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
PKD2L1	PRKACA	P17612	S	686	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (33)

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	GO_Intercell	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
peripheral	peripheral	UniProt_topology	No	No	No	No	No
peripheral	peripheral	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Page 3 of 4Previous Next

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KCC2A	Q9UQM7	PK2L1	Q9P0L9	Yes	No	Yes	SIGNOR	SIGNOR:37193065
KAPCA	P17612	PK2L1	Q9P0L9	Yes	Yes	No	PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:29230552 SIGNOR:29230552

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	NA	0

Sequence, Structure & Domains16

Sequences

Length

805

Mass

91,982

Sequence

MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQETAYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETVLEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEVPYKREEEALEERRLSRGEIPTLQRS

Alternative Products

Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9P0L9-1; Sequence=Displayed; Name=2; Synonyms=PKDLdel15, PCL-TS, Testis isoform; IsoId=Q9P0L9-2; Sequence=VSP_004730, VSP_004731; Name=3; Synonyms=PKDLdel5; IsoId=Q9P0L9-3; Sequence=VSP_004729; Name=4; Synonyms=PKDLdel456; IsoId=Q9P0L9-4; Sequence=VSP_004728; Name=5; Synonyms=PCL-LV, Liver isoform; IsoId=Q9P0L9-5; Sequence=VSP_053718

Alternative Sequence

225..344; Missing (in isoform 4); 245..319; Missing (in isoform 3); 638..666; Missing (in isoform 5); 751..760; KEQAIWKHPQ -> RFPIKEKRKP (in isoform 2); 761..805; Missing (in isoform 2)

3D Structural Models

Turn

102..104; 119..121; 164..169; 310..313; 526..532

Helix

105..118; 127..137; 148..150; 157..160; 250..253; 278..290; 356..375; 385..419; 429..451; 452..454; 482..498; 511..521; 537..559; 704..731; 734..741

Beta Strand

183..185; 188..194; 202..205; 207..210; 229..232; 238..240; 243..246; 261..264; 298..309; 314..323; 333..339; 499..502; 504..506; 534..536

3D Structure

Electron microscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

780..796; Basic and acidic residues

Coiled Coil

650..686; 700..740

Domain (CC)

The EF-hand domain is not required for channel activation (PubMed:11959145).; DOMAIN: Interaction of the cytoplasmic N- and C-terminal domains is important for the non-selective cation channel activity.

Domain (FT)

633..668; EF-hand

Region

1..59; Disordered; 704..763; Required for homooligomerization; 759..805; Disordered

Protein Families

Polycystin family

Sequence Similarities

Belongs to the polycystin family.

Clinical Relevance2

Drugs (12)

ETHYLISOPROPYLAMILORIDE HCL CITRIC ACID AMILORIDE BENZAMIL FLUFENAMIC ACID CA2+LA3+MALIC ACID FLUFENAMATE GD3+PHENAMIL

Antibody (2)

CAB022621 HPA070002

Supporting Publications4

PMID	Title	Abstract
26884841	Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis.	No abstract available
27312428	A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
39940785	Secretome and Proteome of Extracellular Vesicles Provide Protein Markers of Lung and Colorectal Cancer.	No abstract available