Protein detail
CING
Cingulin
Entry name CING | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Cingulin
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1319
Gene Description
Cingulin
Chromosome
1
Position
151510510-151538692
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificOocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence22
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CGN | PRKAA1 | Q13131 | S | 137 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | Yes | ||
| tight_junction | tight_junction | OmniPath | Yes | Yes | Yes | ||
| secreted | secreted | connectomeDB2020 | Yes | ||||
| secreted | secreted | OmniPath | Yes | ||||
| ligand | ligand | talklr | Yes | Yes | |||
| ligand | ligand | connectomeDB2020 | Yes | Yes | |||
| ligand | ligand | iTALK | Yes | Yes |
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Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AGGF1KIF14NBR1SCGN | O76038Q14596Q15058Q8N302 | 0:0:0:0 | hu.MAP | |||
| AGGF1NBR1SCGN | O76038Q14596Q8N302 | 0:0:0 | hu.MAP | |||
| RAVER1SCGN | O76038Q8IY67 | 0:0 | hu.MAP2 | |||
| CGNCGNL1LMNB2NOL6RPL9P8RRP7A | P32969Q03252Q0VF96Q9H6R4Q9P2M7Q9Y3A4 | 0:0:0:0:0:0 | hu.MAP2 | |||
| CGNCGNL1RPL9P8 | P32969Q0VF96Q9P2M7 | 0:0:0 | hu.MAP2 | |||
| CGNL1ELOF1 | P60002Q0VF96 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
1,203
Mass
137,057
Sequence
MEQAPNMAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9P2M7-1; Sequence=Displayed; Name=2; IsoId=Q9P2M7-2; Sequence=VSP_037039, VSP_037040
Alternative Sequence
704..777; KMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQL -> RGVGTGLRRWRLRVSGGLRSQRVWKVTCHGYVLTSSWVLGMWFKEARIWQGEDTCICVGVGFSEKRLAGGSCSL (in isoform 2); 778..1203; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
207..231; Basic and acidic residues; 232..266; Polar residues; 1044..1053; Low complexity
Motif
48..62; ZIM
Coiled Coil
358..1160
Domain (CC)
Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.
Region
7..357; Head; 25..48; Disordered; 54..67; Interaction with TJP1/ZO1; 89..127; Disordered; 186..266; Disordered; 1034..1053; Disordered; 1154..1181; Disordered; 1161..1203; Tail
Protein Families
Cingulin family
Sequence Similarities
Belongs to the cingulin family.
Clinical Relevance
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No related sentences available |