Protein detail

CING

Cingulin

Entry name CING	UniProt ID Q9P2M7	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Cingulin

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000143375

Entrez Gene Symbol

CGN

Gene Synonym

KIAA1319

Gene Description

Cingulin

Chromosome

Position

151510510-151538692

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificOocytes

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04530 Tight junction

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence22

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CGN	PRKAA1	Q13131	S	137	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ligand	ligand	CellTalkDB	Yes	No	Yes	No	No
ligand	ligand	Ramilowski2015	Yes	No	Yes	No	No
ligand	ligand	LRdb	Yes	No	Yes	No	No
ligand	ligand	OmniPath	Yes	No	Yes	No	No

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Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
AGGF1 KIF14 NBR1 SCGN	O76038 Q14596 Q15058 Q8N302	0:0:0:0	hu.MAP
AGGF1 NBR1 SCGN	O76038 Q14596 Q8N302	0:0:0	hu.MAP
RAVER1 SCGN	O76038 Q8IY67	0:0	hu.MAP2
CGN CGNL1 LMNB2 NOL6 RPL9P8 RRP7A	P32969 Q03252 Q0VF96 Q9H6R4 Q9P2M7 Q9Y3A4	0:0:0:0:0:0	hu.MAP2
CGN CGNL1 RPL9P8	P32969 Q0VF96 Q9P2M7	0:0:0	hu.MAP2
CGNL1 ELOF1	P60002 Q0VF96	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38343172

Sequence, Structure & Domains12

Sequences

Length

1,203

Mass

137,057

Sequence

MEQAPNMAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9P2M7-1; Sequence=Displayed; Name=2; IsoId=Q9P2M7-2; Sequence=VSP_037039, VSP_037040

Alternative Sequence

704..777; KMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQL -> RGVGTGLRRWRLRVSGGLRSQRVWKVTCHGYVLTSSWVLGMWFKEARIWQGEDTCICVGVGFSEKRLAGGSCSL (in isoform 2); 778..1203; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

207..231; Basic and acidic residues; 232..266; Polar residues; 1044..1053; Low complexity

Motif

48..62; ZIM

Coiled Coil

358..1160

Domain (CC)

Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.

Region

7..357; Head; 25..48; Disordered; 54..67; Interaction with TJP1/ZO1; 89..127; Disordered; 186..266; Disordered; 1034..1053; Disordered; 1154..1181; Disordered; 1161..1203; Tail

Protein Families

Cingulin family

Sequence Similarities

Belongs to the cingulin family.

Clinical Relevance4

Antibody (4)

CAB017193 HPA027586 HPA027587 HPA027657

Interaction Protein (6)

ENSG00000104067ENSG00000108953ENSG00000164924ENSG00000166913ENSG00000170027ENSG00000175793

Interaction Count

Interaction Dataset (3)

intact_biogridbiogrid_opencellintact_biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available