Protein detail

RHCG

Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2)

Protein symbol RHCG	UniProt ID Q9UBD6	EVMP score 0.38
Frequency	Transmembrane count 12	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2)

Protein Class

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores

Transmembrane

10..30; Helical; 61..81; Helical; 86..106; Helical; 124..144; Helical; 149..169; Helical; 178..200; Helical; 219..239; Helical; 251..271; Helical; 282..302; Helical; 304..324; Helical; 346..366; Helical; 395..415; Helical

Transmembrane Count

Ensembl

ENSG00000140519

Entrez Gene Symbol

RHCG

Gene Synonym

C15orf6PDRC2RHGKSLC42A3

Gene Description

Rh family C glycoprotein

Chromosome

Position

89471398-89496589

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificcDCSingle-Nuclei Brain Specificendothelial cellSecretome LocationSecreted to bloodSecretome FunctionImmunity

Function & Pathway

Protein Function

Transporters:Transporter channels and pores

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
slc	transporter	Surfaceome	No	Yes	No	No	No
slc42_rh	transporter	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	RHCG SCARB2	Q14108 Q9UBD6	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	2	35611462 33919183

Sequence, Structure & Domains

Sequences

Length

479

Mass

53,179

Sequence

MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRYPSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVVGVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPFWGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP

3D Structural Models

Turn

114..116; 181..184; 208..210; 236..239; 293..299; 440..442

Helix

10..29; 55..71; 73..77; 78..80; 85..109; 122..142; 148..170; 185..198; 204..207; 215..235; 243..270; 279..284; 285..287; 288..292; 303..332; 340..343; 345..360; 385..416; 432..434

Beta Strand

117..119

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

Ammonium transporter (TC 2.A.49) family
Rh subfamily

Sequence Similarities

Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.

Clinical Relevance

Antibody

HPA041874 HPA043317

Interaction Protein

ENSG00000184349

Interaction Count

Interaction Dataset

intact_biogrid