Protein detail

RHCG

Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2)

Entry name
RHCG
UniProt ID
EVMP confidence score
0.38
Supporting publications (n)
Transmembrane count
12
Protein classification
Metabolic proteinsPredicted membrane proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information12
Protein Names
Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
10..30; Helical; 61..81; Helical; 86..106; Helical; 124..144; Helical; 149..169; Helical; 178..200; Helical; 219..239; Helical; 251..271; Helical; 282..302; Helical; 304..324; Helical; 346..366; Helical; 395..415; Helical
Transmembrane Count
12
Entrez Gene Symbol
Gene Synonym (4)
C15orf6PDRC2RHGKSLC42A3
Gene Description
Rh family C glycoprotein
Chromosome
15
Position
89471398-89496589
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificcDCSingle-Nuclei Brain Specificendothelial cellSecretome LocationSecreted to bloodSecretome FunctionImmunity
Function & Pathway6
Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneTopDBNoNoNoNoNo
transmembranetransmembraneLOCATENoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
apical_cell_membraneplasma_membraneUniProt_locationNoNoNoNoNo
apical_cell_membraneplasma_membraneRamilowski_locationNoNoNoNoNo
plasma_membraneplasma_membraneRamilowski_locationNoNoNoNoNo
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
RHCGSCARB2Q14108Q9UBD60:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometry23561146233919183
Sequence, Structure & Domains9

Sequences

Length
479
Mass
53,179
Sequence
MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRYPSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVVGVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPFWGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP

3D Structural Models

Turn
114..116; 181..184; 208..210; 236..239; 293..299; 440..442
Helix
10..29; 55..71; 73..77; 78..80; 85..109; 122..142; 148..170; 185..198; 204..207; 215..235; 243..270; 279..284; 285..287; 288..292; 303..332; 340..343; 345..360; 385..416; 432..434
Beta Strand
117..119
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Protein Families (2)
  • Ammonium transporter (TC 2.A.49) family
  • Rh subfamily
Sequence Similarities
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
Clinical Relevance4
Interaction Protein
ENSG00000184349
Interaction Count
1
Interaction Dataset
intact_biogrid