Protein detail

LPAR3

Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)

Entry name LPAR3	UniProt ID Q9UBY5	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)

Protein Function (2)

G-protein coupled receptors:Lysolipids receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

32..52; Helical; Name=1; 68..88; Helical; Name=2; 102..124; Helical; Name=3; 147..167; Helical; Name=4; 187..207; Helical; Name=5; 241..261; Helical; Name=6; 277..297; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000171517

Entrez Gene Symbol

LPAR3

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Cell SpecificAdipocytesBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells

Function & Pathway7

Protein Function (2)

G-protein coupled receptors:Lysolipids receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (5)

Reactome (6)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence63

Ligand-Receptor Signaling (52)

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No

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Regulatory Interaction Network (10)

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LPAR3	Q9UBY5	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR3	Q9UBY5	GNA12	Q03113	Yes	Yes	No	KEGG-MEDICUSWangCui2007SIGNOR	SIGNOR:15856019 SIGNOR:22863277
LPAR3	Q9UBY5	GNAL	P38405	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR3	Q9UBY5	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:11093753 SIGNOR:31160049
LPAR3	Q9UBY5	GNA13	Q14344	Yes	Yes	No	KEGG-MEDICUSWangCui2007SIGNOR	SIGNOR:15856019 SIGNOR:22863277
LPAR3	Q9UBY5	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR3	Q9UBY5	GNA14	O95837	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049
LPAR3	Q9UBY5	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR3	Q9UBY5	GNAQ	P50148	Yes	Yes	No	KEGG-MEDICUSWangCui2007SIGNOR	SIGNOR:12531543 SIGNOR:31160049
LPAR3	Q9UBY5	GNA15	P30679	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	ELISA	1	37322475

Sequence, Structure & Domains5

Sequences

Length

353

Mass

40,128

Sequence

MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Related Diseases (2)

Fibrosis Systemic sclerosis

Biomarker

Phase 2

Drugs (2)

SAR 100842.00 CHEMBL:CHEMBL519155

Supporting Publications2

PMID	Title	Abstract
36114323	Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.	No abstract available
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No abstract available