Protein detail
LPAR3
Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)
Protein symbol LPAR3 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
32..52; Helical; Name=1; 68..88; Helical; Name=2; 102..124; Helical; Name=3; 147..167; Helical; Name=4; 187..207; Helical; Name=5; 241..261; Helical; Name=6; 277..297; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAdipocytesBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| lysosphingolipid_lysophosphatidic_acid_edg_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_lipid_lysophospholipid_lpa | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
10 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LPAR3 | Q9UBY5 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA12 | Q03113 | Yes | Yes | No | KEGG-MEDICUSWangCui2007SIGNOR | SIGNOR:15856019SIGNOR:22863277 |
| LPAR3 | Q9UBY5 | GNAL | P38405 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:11093753SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA13 | Q14344 | Yes | Yes | No | KEGG-MEDICUSWangCui2007SIGNOR | SIGNOR:15856019SIGNOR:22863277 |
| LPAR3 | Q9UBY5 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNAQ | P50148 | Yes | Yes | No | KEGG-MEDICUSWangCui2007SIGNOR | SIGNOR:12531543SIGNOR:31160049 |
| LPAR3 | Q9UBY5 | GNA15 | P30679 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | ELISA | 1 | 37322475 |
Sequence, Structure & Domains
Sequences
Length
353
Mass
40,128
Sequence
MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
3D Structural Models
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.