Protein detail

ADDG

Gamma-adducin (Adducin-like protein 70)

Entry name
ADDG
UniProt ID
Q9UEY8
EVMP confidence score
0.72
Supporting publications (n)
16
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
Basic Information
Protein Names
Gamma-adducin (Adducin-like protein 70)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Predicted intracellular proteins
Ensembl
ENSG00000148700
Entrez Gene Symbol
ADD3
Gene Synonym
ADDL
Gene Description
Adducin 3
Chromosome
10
Position
109996368-110135565
Supporting publications (n)
16
EVMP confidence score
0.72
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Predicted intracellular proteins
Cellular Component (9)
Molecular Function (4)
Biological Process (3)
Reactome (6)
Canonical Pathways
M286 Pid tgfbr pathway
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence22

Enzyme-Mediated Modification (12)

12 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
ADD3PRKACAP17612S693phosphorylationKEAKEA:9607561
ADD3RPS6KA3P51812S693phosphorylationKEAKEA:17570479
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Ligand-Receptor Signaling (7)

7 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
KPCAP17252ADDGQ9UEY8YesYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAKinexus_KEAHPRD_KEASIGNOR_ProtMapperHPRD-phosHPRD-phos:11895774HPRD:11895774HPRD-phos:18452278SIGNOR:11895774ProtMapper:19651622ProtMapper:20166139ProtMapper:20068231HPRD-phos:20068231HPRD-phos:18669648ProtMapper:11895774ProtMapper:18669648ProtMapper:18452278KEA:9607561HPRD-phos:19651622KEA:11895774HPRD-phos:20166139

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ADD3ANKRD29Q8N6D5Q9UEY80:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion ChromatographyMass spectrometry131414377
Sequence, Structure & Domains

Sequences

Length
706
Mass
79,155
Sequence
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLALQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGELEEYKRTIERKQQGLEDAEQELLSDDASSVSQIQSQTQSPQNVPEKLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVSRLSTSTTIENIEITIKSPEKIEEVLSPEGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=2; Synonyms=Long; IsoId=Q9UEY8-1; Sequence=Displayed; Name=1; Synonyms=Short; IsoId=Q9UEY8-2; Sequence=VSP_000188
Alternative Sequence
576..607; Missing (in isoform 1)

Domain & Motif Annotations

Compositional Bias
1..10; Polar residues; 589..602; Low complexity; 682..706; Basic residues
Domain (CC)
Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
Region
1..20; Disordered; 471..497; Disordered; 535..555; Disordered; 575..610; Disordered; 666..706; Disordered; 684..701; Interaction with calmodulin
Protein Families (2)
  • Aldolase class II family
  • Adducin subfamily
Sequence Similarities
Belongs to the aldolase class II family. Adducin subfamily.
Clinical Relevance
Disease Involvement
Disease variant
Drugs (19)
DIMZQ-16GLPG1205UNDECANOIC ACID2-HYDROXY CAPRIC ACIDLAURIC ACID3-HYDROXY CAPRIC ACID2-HYDROXYLAURIC ACIDPSB-1584PSB-17365EMBELINPSB-16434PBI-4547DL-1753-HYDROXYLAURIC ACIDDECANOIC ACID6-N-OCTYLAMINOURACILSETOGEPRAM6-NONYLPYRIDINE-2,4-DIOL
Antibody (2)
CAB009797HPA035696
Supporting Publications16
PMIDTitleRelated sentences
39207047The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.No related sentences available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No related sentences available
40465195Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.No related sentences available
40840701Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.No related sentences available
40985879TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.No related sentences available
41307968Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.No related sentences available
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