Protein detail
KCNN3
Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)
Protein symbol KCNN3 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count 6 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransportersVoltage-gated ion channels |
Basic Information
Protein Names
Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Other congenital malformations
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- FDA approved drug targets:Small molecule drugs
Transmembrane
288..308; Helical; Name=Segment S1; 315..335; Helical; Name=Segment S2; 366..386; Helical; Name=Segment S3; 405..425; Helical; Name=Segment S4; 454..474; Helical; Name=Segment S5; 523..543; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
hSK3KCa2.3SKCA3
Gene Description
Potassium calcium-activated channel subfamily N member 3
Chromosome
1
Position
154697455-154870281
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificKupffer cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Other congenital malformations
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| calcium_activated_potassium | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| calcium_activated_potassium | ion_channel | Almen2009 | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | NA | 0 |
Sequence, Structure & Domains
Sequences
Length
731
Mass
81,385
Sequence
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UGI6-1; Sequence=Displayed; Name=2; IsoId=Q9UGI6-2; Sequence=VSP_039461, VSP_039462; Name=3; Synonyms=SK3-1B; IsoId=Q9UGI6-3; Sequence=VSP_047641
Alternative Sequence
1..313; Missing (in isoform 3); 1..305; Missing (in isoform 2); 306..310; WGLYS -> MERPI (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..11; Basic and acidic residues; 30..40; Low complexity; 41..51; Pro residues; 52..95; Low complexity; 112..132; Polar residues; 138..147; Low complexity; 239..256; Polar residues; 717..731; Low complexity
Coiled Coil
642..669
Domain (CC)
The coiled-coil domaim mediates heteromeic assembly.
Region
1..170; Disordered; 239..258; Disordered; 561..637; Calmodulin-binding; 709..731; Disordered
Protein Families
- Potassium channel KCNN family
- KCa2.3/KCNN3 subfamily
Sequence Similarities
Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Related Diseases
Biomarker
Clinical trial
Drug Targets
FDA approved drug targets
Drugs