Protein detail

KCNN3

Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)

Entry name KCNN3	UniProt ID Q9UGI6	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count 6	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransportersVoltage-gated ion channels

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)

Protein Class (6)

Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransportersVoltage-gated ion channels

Protein Function (5)

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Congenital malformations:Other congenital malformations
Voltage-gated ion channels:Calcium-Activated Potassium Channels
FDA approved drug targets:Small molecule drugs

Transmembrane

288..308; Helical; Name=Segment S1; 315..335; Helical; Name=Segment S2; 366..386; Helical; Name=Segment S3; 405..425; Helical; Name=Segment S4; 454..474; Helical; Name=Segment S5; 523..543; Helical; Name=Segment S6

Transmembrane Count

Ensembl

ENSG00000143603

Entrez Gene Symbol

KCNN3

Gene Synonym (3)

hSK3KCa2.3SKCA3

Gene Description

Potassium calcium-activated channel subfamily N member 3

Chromosome

Position

154697455-154870281

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificKupffer cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway7

Protein Function (5)

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Congenital malformations:Other congenital malformations
Voltage-gated ion channels:Calcium-Activated Potassium Channels
FDA approved drug targets:Small molecule drugs

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence26

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
voltage_gated	ion_channel	Almen2009	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
peripheral	peripheral	UniProt_topology	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	NA	0

Sequence, Structure & Domains11

Sequences

Length

731

Mass

81,385

Sequence

MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UGI6-1; Sequence=Displayed; Name=2; IsoId=Q9UGI6-2; Sequence=VSP_039461, VSP_039462; Name=3; Synonyms=SK3-1B; IsoId=Q9UGI6-3; Sequence=VSP_047641

Alternative Sequence

1..313; Missing (in isoform 3); 1..305; Missing (in isoform 2); 306..310; WGLYS -> MERPI (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1..11; Basic and acidic residues; 30..40; Low complexity; 41..51; Pro residues; 52..95; Low complexity; 112..132; Polar residues; 138..147; Low complexity; 239..256; Polar residues; 717..731; Low complexity

Coiled Coil

642..669

Domain (CC)

The coiled-coil domaim mediates heteromeic assembly.

Region

1..170; Disordered; 239..258; Disordered; 561..637; Calmodulin-binding; 709..731; Disordered

Protein Families (2)

Potassium channel KCNN family
KCa2.3/KCNN3 subfamily

Sequence Similarities

Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.

Clinical Relevance6

Disease Involvement (2)

Disease variantFDA approved drug targets

Related Diseases

Myelopathy

Biomarker

Clinical trial

Drug Targets

FDA approved drug targets

Drugs

DEQUALINIUM

Antibody (2)

HPA017990 HPA057127

Supporting Publications5

PMID	Title	Abstract
30451371	Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance.	No abstract available
33017416	Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers.	No abstract available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available
41073401	Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids.	No abstract available