Protein detail
SEPT3
Neuronal-specific septin-3
Entry name SEPT3 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 16 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Neuronal-specific septin-3
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
SEP3SEPT3
Gene Description
Septin 3
Chromosome
22
Position
41969443-41998221
Supporting publications (n)
16
EVMP confidence score
0.60
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificcerebellar inhibitoryBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cellsSecretome LocationSecreted in female reproductive systemSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (6)
Molecular Function (6)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence13
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SEPTIN3 | PRKG1 | Q13976 | S | 91 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORHPRD | HPRD:15107017SIGNOR:15107017 |
| SEPTIN3 | PRKG1 | Q13976 | S | 78 | phosphorylation | KEA | KEA:15107017 |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KGP1 | Q13976 | SEPT3 | Q9UH03 | Yes | Yes | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | ProtMapper:15107017HPRD:15107017HPRD-phos:15107017SIGNOR:15107017KEA:15107017 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ANLNRNF40SEPTIN11SEPTIN14SEPTIN3SEPTIN6 | O75150Q14141Q6ZU15Q9NQW6Q9NVA2Q9UH03 | 0:0:0:0:0:0 | hu.MAP | |||
| SEPTIN3SEPTIN7 | Q16181Q9UH03 | 2:2 | PDB | PDB:6uqq | ||
| PCMTD2SEPTIN14SEPTIN3 | Q6ZU15Q9NV79Q9UH03 | 0:0:0 | hu.MAP | |||
| SEPTIN3 | Q9UH03 | 2 | PDB | PDB:3sopPDB:4z54 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 1 | 38576002 |
Sequence, Structure & Domains
Sequences
Length
358
Mass
40,704
Sequence
MSKGLPETRTDAAMSELVPEPRPKPAVPMKPMSINSNLLGYIGIDTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKTVEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNIARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNIIPVIAKADTMTLEEKSEFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKRVLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGGLPPGEGLLGTVLPPVPATPCPTAE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A, SEP3A; IsoId=Q9UH03-1; Sequence=Displayed; Name=2; Synonyms=B, SEP3B; IsoId=Q9UH03-2; Sequence=VSP_006049; Name=3; Synonyms=C, SEP3C; IsoId=Q9UH03-3; Sequence=VSP_025398, VSP_025399
Alternative Sequence
68..83; GQSGLGKSTLVNTLFK -> AGSPLRSTSMSSTRSS (in isoform 3); 84..358; Missing (in isoform 3); 338..358; GEGLLGTVLPPVPATPCPTAE -> VSVDTEESHDSNP (in isoform 2)
3D Structural Models
Turn
127..130; 136..139; 197..199; 292..294; 306..308
Helix
45..52; 74..84; 92..94; 140..156; 187..196; 209..211; 214..230; 239..241; 245..256; 297..305; 309..318; 320..327
Beta Strand
59..69; 70..73; 106..114; 117..125; 132..134; 173..178; 182..184; 202..208; 260..262; 269..272; 275..281; 286..288
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
1..10; Basic and acidic residues
Domain (FT)
58..331; Septin-type G
Region
1..30; Disordered; 68..75; G1 motif; 125..128; G3 motif; 207..210; G4 motif
Protein Families (2)
- TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
- Septin GTPase family
Sequence Similarities
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Clinical Relevance
Interaction Protein (7)
ENSG00000122545ENSG00000125354ENSG00000138758ENSG00000164402ENSG00000168385ENSG00000180096ENSG00000184640
Interaction Count
7
Interaction Dataset (2)
biogrid_opencellintact_biogrid
Supporting Publications16
| PMID | Title | Related sentences |
|---|---|---|
| 30451371 | Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance. | No related sentences available |
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No related sentences available |
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No related sentences available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |
| 38168906 | Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi-omic analysis. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 39409015 | SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy. | No related sentences available |
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