Protein detail

HEG1

Protein HEG homolog 1

Entry name HEG1	UniProt ID Q9ULI3	EVMP confidence score 0.25
Supporting publications (n) 5	Transmembrane count 1	Protein classification Plasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protein HEG homolog 1

Protein Class (2)

Plasma proteinsPredicted membrane proteins

Transmembrane

1249..1269; Helical

Transmembrane Count

Ensembl

ENSG00000173706

Entrez Gene Symbol

HEG1

Gene Synonym (2)

HEGKIAA1237

Gene Description

Heart development protein with EGF like domains 1

Chromosome

Position

124965710-125055997

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization6

Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificcerebellar inhibitoryBlood Cell SpecificT-regBlood Lineage SpecificT-cells

Function & Pathway5

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

KEGG

hsa04520 Adherens junction

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence31

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	Yes	No
ecm	ecm	OmniPath	Yes	No	Yes	Yes	No
extracellular	extracellular	DGIdb	No	No	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
KRIT1-HEG1-RAP1B complex	HEG1 KRIT1 RAP1B	O00522 P61224 Q9ULI3	1:1:1	CORUMPDB	PDB:4hdqCORUM:7058	23814056
	HEG1 KRIT1	O00522 Q9ULI3	2:2	PDB	PDB:3u7d

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass Spectrometry	2	38113368 38354507

Sequence, Structure & Domains9

Sequences

Length

1,381

Mass

147,461

Sequence

MASPRASRWPPPLLLLLLPLLLLPPAAPGTRDPPPSPARRALSLAPLAGAGLELQLERRPEREPPPTPPRERRGPATPGPSYRAPEPGAATQRGPSGRAPRGGSADAAWKHWPESNTEAHVENITFYQNQEDFSTVSSKEGVMVQTSGKSHAASDAPENLTLLAETADARGRSGSSSRTNFTILPVGYSLEIATALTSQSGNLASESLHLPSSSSEFDERIAAFQTKSGTASEMGTERAMGLSEEWTVHSQEATTSAWSPSFLPALEMGELTTPSRKRNSSGPDLSWLHFYRTAASSPLLDLSSSSESTEKLNNSTGLQSSSVSQTKTMHVATVFTDGGPRTLRSLTVSLGPVSKTEGFPKDSRIATTSSSVLLSPSAVESRRNSRVTGNPGDEEFIEPSTENEFGLTSLRWQNDSPTFGEHQLASSSEVQNGSPMSQTETVSRSVAPMRGGEITAHWLLTNSTTSADVTGSSASYPEGVNASVLTQFSDSTVQSGGSHTALGDRSYSESSSTSSSESLNSSAPRGERSIAGISYGQVRGTAIEQRTSSDHTDHTYLSSTFTKGERALLSITDNSSSSDIVESSTSYIKISNSSHSEYSSFFHAQTERSNISSYDGEYAQPSTESPVLHTSNLPSYTPTINMPNTSVVLDTDAEFVSDSSSSSSSSSSSSSSGPPLPLPSVSQSHHLFSSILPSTRASVHLLKSTSDASTPWSSSPSPLPVSLTTSTSAPLSVSQTTLPQSSSTPVLPRARETPVTSFQTSTMTSFMTMLHSSQTADLKSQSTPHQEKVITESKSPSLVSLPTESTKAVTTNSPLPPSLTESSTEQTLPATSTNLAQMSPTFTTTILKTSQPLMTTPGTLSSTASLVTGPIAVQTTAGKQLSLTHPEILVPQISTEGGISTERNRVIVDATTGLIPLTSVPTSAKEMTTKLGVTAEYSPASRSLGTSPSPQTTVVSTAEDLAPKSATFAVQSSTQSPTTVSSSASVNSCAVNPCLHNGECVADNTSRGYHCRCPPSWQGDDCSVDVNECLSNPCPSTAMCNNTQGSFICKCPVGYQLEKGICNLVRTFVTEFKLKRTFLNTTVEKHSDLQEVENEITKTLNMCFSALPSYIRSTVHASRESNAVVISLQTTFSLASNVTLFDLADRMQKCVNSCKSSAEVCQLLGSQRRIFRAGSLCKRKSPECDKDTSICTDLDGVALCQCKSGYFQFNKMDHSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGIALIVTCCRKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTSVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULI3-1; Sequence=Displayed; Name=2; IsoId=Q9ULI3-2; Sequence=VSP_025275, VSP_025276

Alternative Sequence

986..1012; VNSCAVNPCLHNGECVADNTSRGYHCR -> GKTQSHKHMLTARPSPALRATWGSGFM (in isoform 2); 1013..1381; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

25..37; Pro residues; 38..52; Low complexity; 55..74; Basic and acidic residues; 93..105; Low complexity; 301..316; Low complexity; 424..444; Polar residues; 508..522; Low complexity; 620..648; Polar residues; 657..680; Low complexity; 706..748; Low complexity; 774..784; Polar residues; 792..809; Polar residues; 810..825; Low complexity

Domain (FT)

985..1023; EGF-like 1; 1025..1063; EGF-like 2; calcium-binding

Region

24..108; Disordered; 301..325; Disordered; 376..447; Disordered; 491..529; Disordered; 612..680; Disordered; 706..757; Disordered; 774..830; Disordered

Clinical Relevance1

Antibody (2)

HPA010952 HPA011559

Supporting Publications5

PMID	Title	Abstract
30301952	A position on vision.	No abstract available
36114323	Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.	No abstract available
37576973	The proteome and phosphoproteome of circulating extracellular vesicle-enriched preparations are associated with characteristic clinical features in type 1 diabetes.	No abstract available
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No abstract available
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No abstract available