Protein detail
HEG1
Protein HEG homolog 1
Entry name HEG1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 5 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Protein HEG homolog 1
Protein Class (2)
Plasma proteinsPredicted membrane proteins
Transmembrane
1249..1269; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
HEGKIAA1237
Gene Description
Heart development protein with EGF like domains 1
Chromosome
3
Position
124965710-125055997
Supporting publications (n)
5
EVMP confidence score
0.25
Fluorescence & Localization6
Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificcerebellar inhibitoryBlood Cell SpecificT-regBlood Lineage SpecificT-cells
Function & Pathway5
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence31
Ligand-Receptor Signaling (28)
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_predicted | transmembrane | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
Protein Complex Composition (2)
Sequence, Structure & Domains9
Sequences
Length
1,381
Mass
147,461
Sequence
MASPRASRWPPPLLLLLLPLLLLPPAAPGTRDPPPSPARRALSLAPLAGAGLELQLERRPEREPPPTPPRERRGPATPGPSYRAPEPGAATQRGPSGRAPRGGSADAAWKHWPESNTEAHVENITFYQNQEDFSTVSSKEGVMVQTSGKSHAASDAPENLTLLAETADARGRSGSSSRTNFTILPVGYSLEIATALTSQSGNLASESLHLPSSSSEFDERIAAFQTKSGTASEMGTERAMGLSEEWTVHSQEATTSAWSPSFLPALEMGELTTPSRKRNSSGPDLSWLHFYRTAASSPLLDLSSSSESTEKLNNSTGLQSSSVSQTKTMHVATVFTDGGPRTLRSLTVSLGPVSKTEGFPKDSRIATTSSSVLLSPSAVESRRNSRVTGNPGDEEFIEPSTENEFGLTSLRWQNDSPTFGEHQLASSSEVQNGSPMSQTETVSRSVAPMRGGEITAHWLLTNSTTSADVTGSSASYPEGVNASVLTQFSDSTVQSGGSHTALGDRSYSESSSTSSSESLNSSAPRGERSIAGISYGQVRGTAIEQRTSSDHTDHTYLSSTFTKGERALLSITDNSSSSDIVESSTSYIKISNSSHSEYSSFFHAQTERSNISSYDGEYAQPSTESPVLHTSNLPSYTPTINMPNTSVVLDTDAEFVSDSSSSSSSSSSSSSSGPPLPLPSVSQSHHLFSSILPSTRASVHLLKSTSDASTPWSSSPSPLPVSLTTSTSAPLSVSQTTLPQSSSTPVLPRARETPVTSFQTSTMTSFMTMLHSSQTADLKSQSTPHQEKVITESKSPSLVSLPTESTKAVTTNSPLPPSLTESSTEQTLPATSTNLAQMSPTFTTTILKTSQPLMTTPGTLSSTASLVTGPIAVQTTAGKQLSLTHPEILVPQISTEGGISTERNRVIVDATTGLIPLTSVPTSAKEMTTKLGVTAEYSPASRSLGTSPSPQTTVVSTAEDLAPKSATFAVQSSTQSPTTVSSSASVNSCAVNPCLHNGECVADNTSRGYHCRCPPSWQGDDCSVDVNECLSNPCPSTAMCNNTQGSFICKCPVGYQLEKGICNLVRTFVTEFKLKRTFLNTTVEKHSDLQEVENEITKTLNMCFSALPSYIRSTVHASRESNAVVISLQTTFSLASNVTLFDLADRMQKCVNSCKSSAEVCQLLGSQRRIFRAGSLCKRKSPECDKDTSICTDLDGVALCQCKSGYFQFNKMDHSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGLLLILGIALIVTCCRKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVYYSPTSVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULI3-1; Sequence=Displayed; Name=2; IsoId=Q9ULI3-2; Sequence=VSP_025275, VSP_025276
Alternative Sequence
986..1012; VNSCAVNPCLHNGECVADNTSRGYHCR -> GKTQSHKHMLTARPSPALRATWGSGFM (in isoform 2); 1013..1381; Missing (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
25..37; Pro residues; 38..52; Low complexity; 55..74; Basic and acidic residues; 93..105; Low complexity; 301..316; Low complexity; 424..444; Polar residues; 508..522; Low complexity; 620..648; Polar residues; 657..680; Low complexity; 706..748; Low complexity; 774..784; Polar residues; 792..809; Polar residues; 810..825; Low complexity
Domain (FT)
985..1023; EGF-like 1; 1025..1063; EGF-like 2; calcium-binding
Region
24..108; Disordered; 301..325; Disordered; 376..447; Disordered; 491..529; Disordered; 612..680; Disordered; 706..757; Disordered; 774..830; Disordered
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 30301952 | A position on vision. | No abstract available |
| 36114323 | Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment. | No abstract available |
| 37576973 | The proteome and phosphoproteome of circulating extracellular vesicle-enriched preparations are associated with characteristic clinical features in type 1 diabetes. | No abstract available |
| 38343172 | Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles. | No abstract available |
| 40595564 | Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome. | No abstract available |