Protein detail

NP1L2

Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked) (Histone chaperone NAP1L2)

Entry name NP1L2	UniProt ID Q9ULW6	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked) (Histone chaperone NAP1L2)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000186462

Entrez Gene Symbol

NAP1L2

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificblood vesselCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificvascular associated smooth muscle cellBlood Cell SpecificNK-cellBlood Lineage Specificdendritic cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence17

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (12)

12 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster548	FBXO11 NAP1L1 NAP1L2 NAP1L3 NAP1L4 NAP1L5	P55209 Q86XK2 Q96NT1 Q99457 Q99733 Q9ULW6	1:1:1:1:1:1	Compleat	Compleat:HC2707	22036573
NAP-Z	H2AZ1 H2AZ2 H2BC1 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC5 H2BC7 H2BC9 H2BW1 H2BW2 NAP1L1 NAP1L2 NAP1L3 NAP1L4 NAP1L5	O60814 P06899 P0C0S5 P0C1H6 P23527 P33778 P55209 P58876 P62807 Q16778 Q5QNW6 Q71UI9 Q7Z2G1 Q8N257 Q93079 Q96A08 Q96NT1 Q99457 Q99733 Q99877 Q99879 Q99880 Q9ULW6	1:1:1:1:1:1:1:1:5:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1732	14645854
chromatin assembly complex	CHAF1A CHAF1B NAP1L1 NAP1L2 NAP1L3 NAP1L4 NOC2L TP53	P04637 P55209 Q13111 Q13112 Q99457 Q99733 Q9ULW6 Q9Y3T9	1:1:1:1:1:1:1:1	Compleat	Compleat:HC2891	8976385 8297347 8789438 9325046 16322561 7600578
	COIL FBL GXYLT2 LYST NAP1L2 NOM1 PINX1 ZNF430 ZNF496 ZNF93	A0PJZ3 P22087 P35789 P38432 Q5C9Z4 Q96BK5 Q96IT1 Q99698 Q9H8G1 Q9ULW6	0:0:0:0:0:0:0:0:0:0	hu.MAP2
	FBL NAP1L2 NHP2 RRP9 TGS1	O43818 P22087 Q96RS0 Q9NX24 Q9ULW6	0:0:0:0:0	hu.MAP2
	COIL FBL IFI16 NAP1L2 TGS1 WDR43 ZNF430 ZNF93	P22087 P35789 P38432 Q15061 Q16666 Q96RS0 Q9H8G1 Q9ULW6	0:0:0:0:0:0:0:0	hu.MAP
	COIL FBL NAP1L2 SRFBP1 TGS1 WDR43 ZNF93	P22087 P35789 P38432 Q15061 Q8NEF9 Q96RS0 Q9ULW6	0:0:0:0:0:0:0	hu.MAP
	FBL NAP1L2 PINX1 TGS1 WDR43 WDR75 YBX2 ZNF93	P22087 P35789 Q15061 Q8IWA0 Q96BK5 Q96RS0 Q9ULW6 Q9Y2T7	0:0:0:0:0:0:0:0	hu.MAP
	FBL NAP1L2 WDR43 ZNF93	P22087 P35789 Q15061 Q9ULW6	0:0:0:0	hu.MAP
	DDX51 FBL NAP1L2 ZNF93	P22087 P35789 Q8N8A6 Q9ULW6	0:0:0:0	hu.MAP

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Sequence, Structure & Domains10

Sequences

Length

460

Mass

52,542

Sequence

MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ULW6-1; Sequence=Displayed; Name=2; IsoId=Q9ULW6-2; Sequence=VSP_057064

Alternative Sequence

1..142; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1..11; Basic and acidic residues; 27..36; Basic and acidic residues; 214..236; Acidic residues

Motif

346..352; Nuclear localization signal

Region

1..88; Disordered; 214..238; Disordered

Protein Families

Nucleosome assembly protein (NAP) family

Sequence Similarities

Belongs to the nucleosome assembly protein (NAP) family.

Supporting Publications2

PMID	Title	Abstract
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available