Protein detail
CAH14
Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)
Protein symbol CAH14 | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count 1 | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)
Protein Class
EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Lyases
Transmembrane
291..311; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Carbonic anhydrase 14
Chromosome
1
Position
150257251-150265078
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificAdipocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Lyases
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 36064647 |
Sequence, Structure & Domains
Sequences
Length
337
Mass
37,668
Sequence
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
3D Structural Models
Turn
141..143
Helix
30..32; 33..36; 38..41; 52..54; 147..150; 172..178; 179..183; 198..201; 238..245
Beta Strand
24..26; 42..44; 66..68; 77..81; 86..89; 95..101; 103..112; 122..125; 131..140; 157..169; 190..193; 209..214; 225..232; 234..237; 249..255; 275..277
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
20..278; Alpha-carbonic anhydrase
Protein Families
Alpha-carbonic anhydrase family
Sequence Similarities
Belongs to the alpha-carbonic anhydrase family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Antibody