Protein detail

CAH14

Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)

Entry name CAH14	UniProt ID Q9ULX7	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count 1	Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)

Protein Class (5)

EnzymesFDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (4)

Predicted intracellular proteins
Enzymes
FDA approved drug targets:Small molecule drugs
ENZYME proteins:Lyases

Transmembrane

291..311; Helical

Transmembrane Count

Ensembl

ENSG00000118298

Entrez Gene Symbol

CA14

Gene Description

Carbonic anhydrase 14

Chromosome

Position

150257251-150265078

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization1

Cell SpecificAdipocytes

Function & Pathway7

Protein Function (4)

Predicted intracellular proteins
Enzymes
FDA approved drug targets:Small molecule drugs
ENZYME proteins:Lyases

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

KEGG (2)

Reactome

R-hsa-1475029 reversible hydration of carbon dioxide

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence23

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGAP1 CA14 DCPS IMMP2L NLRP3	Q07960 Q96C86 Q96P20 Q96T52 Q9ULX7	0:0:0:0:0	hu.MAP2
	CA14 IMMP2L	Q96T52 Q9ULX7	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	36064647

Sequence, Structure & Domains10

Sequences

Length

337

Mass

37,668

Sequence

MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA

3D Structural Models

Turn

141..143

Helix

30..32; 33..36; 38..41; 52..54; 147..150; 172..178; 179..183; 198..201; 238..245

Beta Strand

24..26; 42..44; 66..68; 77..81; 86..89; 95..101; 103..112; 122..125; 131..140; 157..169; 190..193; 209..214; 225..232; 234..237; 249..255; 275..277

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

20..278; Alpha-carbonic anhydrase

Protein Families

Alpha-carbonic anhydrase family

Sequence Similarities

Belongs to the alpha-carbonic anhydrase family.

Clinical Relevance4

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (8)

CHLORTHALIDONE ACETAZOLAMIDE ETHOXZOLAMIDE DORZOLAMIDE BRINZOLAMIDE METHAZOLAMIDE HISTIDINE SULTHIAME

Antibody

HPA008482

Supporting Publications6

PMID	Title	Abstract
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
37563857	Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40730843	Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.	No abstract available