Protein detail

TNF18

Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)

Protein symbol TNF18	UniProt ID Q9UNG2	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)

Protein Function

Predicted intracellular proteins

Transmembrane

28..48; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000120337

Entrez Gene Symbol

TNFSF18

Frequency

EVMP Score

0.25

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Reactome

Mediation Categories

Adhesion and uptake mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

47 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	Yes	Yes	No
transmembrane	transmembrane	TopDB	No	No	Yes	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	Yes	Yes	No
transmembrane	transmembrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TNFSF18	Q9UNG2	3	PDB	PDB:3b94PDB:3b93
	TNFRSF18 TNFSF18	Q9UNG2 Q9Y5U5	2:2	PDB	PDB:7khdPDB:7law

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	7	37427430 39408670 40596376 38037300 39702169 39778061 40689422

Sequence, Structure & Domains

Sequences

Length

177

Mass

20,308

Sequence

MCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS

3D Structural Models

Turn

65..67

Helix

155..157; 160..162

Beta Strand

59..62; 69..72; 78..83; 86..89; 93..101; 109..111; 115..119; 122..127; 130..132; 138..142; 147..154; 164..171

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Domain (FT)

47..170; THD

Protein Families

Tumor necrosis factor family

Sequence Similarities

Belongs to the tumor necrosis factor family.

Clinical Relevance