Protein detail

KCNK6

Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)

Entry name KCNK6	UniProt ID Q9Y257	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification Predicted membrane proteinsTransportersVoltage-gated ion channels

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)

Protein Class (3)

Predicted membrane proteinsTransportersVoltage-gated ion channels

Protein Function (2)

Voltage-gated ion channels:Two-P Potassium Channels
Transporters:Transporter channels and pores

Transmembrane

5..25; Helical; 121..141; Helical; 173..193; Helical; 236..256; Helical

Transmembrane Count

Ensembl

ENSG00000099337

Entrez Gene Symbol

KCNK6

Gene Synonym (2)

K2p6.1TWIK-2

Gene Description

Potassium two pore domain channel subfamily K member 6

Chromosome

Position

38319845-38332076

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway6

Protein Function (2)

Voltage-gated ion channels:Two-P Potassium Channels
Transporters:Transporter channels and pores

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Reactome (6)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence23

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
peripheral	peripheral	UniProt_topology	No	No	No	No	No
peripheral	peripheral	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	KCNK6	Q9Y257	2	PDB	PDB:9mekPDB:9mel

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryFACS	5	22620679 37419919 38926392 38963761 39062552

Sequence, Structure & Domains12

Sequences

Length

313

Mass

33,747

Sequence

MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y257-1; Sequence=Displayed; Name=2; IsoId=Q9Y257-2; Sequence=VSP_006692

Alternative Sequence

1..134; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

295..307; Polar residues

Motif

282..290; Lysosomal targeting signal; 308..312; Lysosomal targeting signal

Domain (CC)

Each subunit contributes two pore-forming domains 1 and 2 which assemble to form a single pore with M2 and M4 transmembrane helices lining the central cavity and M1 and M3 facing the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.

Region

106..111; Selectivity filter 1; 214..219; Selectivity filter 2; 288..313; Disordered

Protein Families

Two pore domain potassium channel (TC 1.A.1.8) family

Sequence Similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Clinical Relevance1

Antibody (2)

CAB022637 HPA040184

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available