Protein detail
KCNK6
Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)
Entry name KCNK6 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransportersVoltage-gated ion channels |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)
Protein Class (3)
Predicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function (2)
- Voltage-gated ion channels:Two-P Potassium Channels
- Transporters:Transporter channels and pores
Transmembrane
5..25; Helical; 121..141; Helical; 173..193; Helical; 236..256; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
K2p6.1TWIK-2
Gene Description
Potassium two pore domain channel subfamily K member 6
Chromosome
19
Position
38319845-38332076
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway6
Protein Function (2)
- Voltage-gated ion channels:Two-P Potassium Channels
- Transporters:Transporter channels and pores
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Reactome (6)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence23
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Protein Complex Composition (1)
Sequence, Structure & Domains12
Sequences
Length
313
Mass
33,747
Sequence
MRRGALLAGALAAYAAYLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGRLGRVVLANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASAQRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVALLGVVVTVCFLVPAVIFAHLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVSDLHGLTELILLPPPCPASFNADEDDRVDILGPQPESHQQLSASSHTDYASIPR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y257-1; Sequence=Displayed; Name=2; IsoId=Q9Y257-2; Sequence=VSP_006692
Alternative Sequence
1..134; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
295..307; Polar residues
Motif
282..290; Lysosomal targeting signal; 308..312; Lysosomal targeting signal
Domain (CC)
Each subunit contributes two pore-forming domains 1 and 2 which assemble to form a single pore with M2 and M4 transmembrane helices lining the central cavity and M1 and M3 facing the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.
Region
106..111; Selectivity filter 1; 214..219; Selectivity filter 2; 288..313; Disordered
Protein Families
Two pore domain potassium channel (TC 1.A.1.8) family
Sequence Similarities
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |