Protein detail

SHAN1

SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)

Protein symbol SHAN1	UniProt ID Q9Y566	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000161681

Entrez Gene Symbol

SHANK1

Gene Synonym

SPANK-1SSTRIPsynamon

Gene Description

SH3 and multiple ankyrin repeat domains 1

Chromosome

Position

50659255-50719802

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04724 Glutamatergic synapse

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	No	No

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Regulatory Interaction Network

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DLGP1	O14490	SHAN1	Q9Y566	Yes	Yes	No	SIGNORHPRDCui2007HINTCA1Wang	HINT:20573181 HPRD:12954649 SIGNOR:28179641 CA1:10433268 HINT:12954649
DLGP2	Q9P1A6	SHAN1	Q9Y566	Yes	Yes	No	SIGNOR	SIGNOR:28179641
DLGP4	Q9Y2H0	SHAN1	Q9Y566	Yes	Yes	No	SIGNOR	SIGNOR:28179641
DLGP5	Q15398	SHAN1	Q9Y566	Yes	Yes	No	SIGNOR	SIGNOR:28179641
SHAN1	Q9Y566	ACTN1	P12814	Yes	Yes	No	SIGNOR	SIGNOR:28179641
DLGP3	O95886	SHAN1	Q9Y566	Yes	Yes	No	SIGNOR	SIGNOR:28179641
FUS	P35637	SHAN1	Q9Y566	Yes	Yes	No	SIGNOR	SIGNOR:32118033
FMR1	Q06787	SHAN1	Q9Y566	Yes	Yes	No	SIGNOR	SIGNOR:32118033
HOME1	Q86YM7	SHAN1	Q9Y566	Yes	Yes	No	HPRDSIGNOR	HPRD:10433269 SIGNOR:17243894

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	FBXO41 SHANK1	Q8TF61 Q9Y566	4:4	PDB	PDB:8s1r
	SHANK1	Q9Y566	2	PDB	PDB:6ywzPDB:6yx2PDB:6yx1PDB:6yx0PDB:7a00

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	2	40098346 37922300

Sequence, Structure & Domains

Sequences

Length

2,161

Mass

224,959

Sequence

MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q9Y566-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9Y566-2; Sequence=VSP_006069, VSP_006070; Name=3; IsoId=Q9Y566-3; Sequence=VSP_006071

Alternative Sequence

1..613; Missing (in isoform 2); 614..654; RSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPG -> MQLMALEQRFGSGLPGGGQPLCLMMSSPLPPPPPHFSCLPA (in isoform 2); 646..654; Missing (in isoform 3)

3D Structural Models

Turn

745..747

Helix

605..607; 710..714; 735..744

Beta Strand

559..563; 569..572; 580..586; 591..596; 599..604; 656..667; 675..680; 694..696; 699..705; 721..725; 748..757

3D Structure

NMR spectroscopy (1); X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

17..32; Low complexity; 33..47; Gly residues; 455..479; Low complexity; 527..542; Gly residues; 920..939; Pro residues; 996..1020; Basic residues; 1127..1144; Pro residues; 1164..1181; Low complexity; 1199..1220; Pro residues; 1241..1252; Basic and acidic residues; 1359..1368; Basic and acidic residues; 1374..1391; Pro residues; 1517..1532; Pro residues; 1583..1609; Pro residues; 1618..1636; Polar residues; 1644..1670; Pro residues; 1678..1688; Basic and acidic residues; 1692..1702; Low complexity; 1703..1718; Gly residues; 1764..1774; Gly residues; 1775..1785; Low complexity; 1844..1855; Pro residues; 1917..1940; Low complexity; 1954..1980; Low complexity; 1996..2006; Low complexity

Repeat

212..245; ANK 1; 246..278; ANK 2; 279..312; ANK 3; 313..345; ANK 4; 346..378; ANK 5; 379..395; ANK 6

Domain (FT)

554..613; SH3; 663..757; PDZ; 2098..2161; SAM

Region

1..53; Disordered; 412..433; Disordered; 455..546; Disordered; 832..886; Disordered; 909..1229; Disordered; 1241..1289; Disordered; 1353..1720; Disordered; 1734..1785; Disordered; 1827..1860; Disordered; 1892..1983; Disordered; 1996..2023; Disordered

Protein Families

SHANK family

Sequence Similarities

Belongs to the SHANK family.

Clinical Relevance

Antibody

HPA032129 HPA032130

Interaction Protein

ENSG00000130234

Interaction Count

Interaction Dataset

intact_biogrid