Protein detail
SHAN1
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
Protein symbol SHAN1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
SPANK-1SSTRIPsynamon
Gene Description
SH3 and multiple ankyrin repeat domains 1
Chromosome
19
Position
50659255-50719802
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0030425 dendrite
- GO:0043005 neuron projection
- GO:0043197 dendritic spine
- GO:0045211 postsynaptic membrane
- GO:0060076 excitatory synapse
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0005515 protein binding
- GO:0017124 SH3 domain binding
- GO:0030160 synaptic receptor adaptor activity
- GO:0031877 somatostatin receptor binding
- GO:0035255 ionotropic glutamate receptor binding
- GO:0042802 identical protein binding
- GO:0044877 protein-containing complex binding
- GO:0071532 ankyrin repeat binding
- GO:0097110 scaffold protein binding
- GO:0098919 structural constituent of postsynaptic density
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | No | No |
| cell_surface | cell_surface | Baccin2019 | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DLGP1 | O14490 | SHAN1 | Q9Y566 | Yes | Yes | No | SIGNORHPRDCui2007HINTCA1Wang | HINT:20573181HPRD:12954649SIGNOR:28179641CA1:10433268HINT:12954649 |
| DLGP2 | Q9P1A6 | SHAN1 | Q9Y566 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| DLGP4 | Q9Y2H0 | SHAN1 | Q9Y566 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| DLGP5 | Q15398 | SHAN1 | Q9Y566 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| SHAN1 | Q9Y566 | ACTN1 | P12814 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| DLGP3 | O95886 | SHAN1 | Q9Y566 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| FUS | P35637 | SHAN1 | Q9Y566 | Yes | Yes | No | SIGNOR | SIGNOR:32118033 |
| FMR1 | Q06787 | SHAN1 | Q9Y566 | Yes | Yes | No | SIGNOR | SIGNOR:32118033 |
| HOME1 | Q86YM7 | SHAN1 | Q9Y566 | Yes | Yes | No | HPRDSIGNOR | HPRD:10433269SIGNOR:17243894 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
2,161
Mass
224,959
Sequence
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q9Y566-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9Y566-2; Sequence=VSP_006069, VSP_006070; Name=3; IsoId=Q9Y566-3; Sequence=VSP_006071
Alternative Sequence
1..613; Missing (in isoform 2); 614..654; RSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPG -> MQLMALEQRFGSGLPGGGQPLCLMMSSPLPPPPPHFSCLPA (in isoform 2); 646..654; Missing (in isoform 3)
3D Structural Models
Turn
745..747
Helix
605..607; 710..714; 735..744
Beta Strand
559..563; 569..572; 580..586; 591..596; 599..604; 656..667; 675..680; 694..696; 699..705; 721..725; 748..757
3D Structure
NMR spectroscopy (1); X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
17..32; Low complexity; 33..47; Gly residues; 455..479; Low complexity; 527..542; Gly residues; 920..939; Pro residues; 996..1020; Basic residues; 1127..1144; Pro residues; 1164..1181; Low complexity; 1199..1220; Pro residues; 1241..1252; Basic and acidic residues; 1359..1368; Basic and acidic residues; 1374..1391; Pro residues; 1517..1532; Pro residues; 1583..1609; Pro residues; 1618..1636; Polar residues; 1644..1670; Pro residues; 1678..1688; Basic and acidic residues; 1692..1702; Low complexity; 1703..1718; Gly residues; 1764..1774; Gly residues; 1775..1785; Low complexity; 1844..1855; Pro residues; 1917..1940; Low complexity; 1954..1980; Low complexity; 1996..2006; Low complexity
Repeat
212..245; ANK 1; 246..278; ANK 2; 279..312; ANK 3; 313..345; ANK 4; 346..378; ANK 5; 379..395; ANK 6
Domain (FT)
554..613; SH3; 663..757; PDZ; 2098..2161; SAM
Region
1..53; Disordered; 412..433; Disordered; 455..546; Disordered; 832..886; Disordered; 909..1229; Disordered; 1241..1289; Disordered; 1353..1720; Disordered; 1734..1785; Disordered; 1827..1860; Disordered; 1892..1983; Disordered; 1996..2023; Disordered
Protein Families
SHANK family
Sequence Similarities
Belongs to the SHANK family.