Protein detail

PCDB4

Protocadherin beta-4 (PCDH-beta-4)

Protein symbol PCDB4	UniProt ID Q9Y5E5	EVMP score 0.50
Frequency 4	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Protocadherin beta-4 (PCDH-beta-4)

Protein Class

Predicted membrane proteins

Transmembrane

690..710; Helical

Transmembrane Count

Ensembl

ENSG00000081818

Entrez Gene Symbol

PCDHB4

Gene Synonym

PCDH-BETA4

Gene Description

Protocadherin beta 4

Chromosome

Position

141121818-141125623

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Cellular Component

Molecular Function

GO:0005509 calcium ion binding

Biological Process

GO:0008150 biological_process

KEGG

hsa04519 Cadherin signaling

Canonical Pathways

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
beta_protocadherin	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometry	6	38225453 39873726 38731868 30071318 27312428 40091455

Sequence, Structure & Domains

Sequences

Length

795

Mass

87,270

Sequence

MKKLGRIHPNRQVLAFILMVFLSQVRLEPIRYSVLEETESGSFVAHLAKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDREELCGPIEPCVLHFQVFLEMPVQFFQGELLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGDSGTGEFKFLKPIFPNLLVQDTGREVKENPKFRNSLVFS

3D Structural Models

Domain & Motif Annotations

Domain (FT)

34..132; Cadherin 1; 137..241; Cadherin 2; 246..346; Cadherin 3; 351..450; Cadherin 4; 455..560; Cadherin 5; 567..670; Cadherin 6

Clinical Relevance

Antibody

HPA014466