Protein detail

PCDB4

Protocadherin beta-4 (PCDH-beta-4)

Entry name PCDB4	UniProt ID Q9Y5E5	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin beta-4 (PCDH-beta-4)

Protein Class

Predicted membrane proteins

Transmembrane

690..710; Helical

Transmembrane Count

Ensembl

ENSG00000081818

Entrez Gene Symbol

PCDHB4

Gene Synonym

PCDH-BETA4

Gene Description

Protocadherin beta 4

Chromosome

Position

141121818-141125623

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway6

Cellular Component (3)

Molecular Function

GO:0005509 calcium ion binding

Biological Process

GO:0008150 biological_process

KEGG

hsa04519 Cadherin signaling

Canonical Pathways (3)

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence30

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometry	6	38225453 39873726 38731868 30071318 27312428 40091455

Sequence, Structure & Domains4

Sequences

Length

795

Mass

87,270

Sequence

MKKLGRIHPNRQVLAFILMVFLSQVRLEPIRYSVLEETESGSFVAHLAKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDREELCGPIEPCVLHFQVFLEMPVQFFQGELLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGDSGTGEFKFLKPIFPNLLVQDTGREVKENPKFRNSLVFS

Domain & Motif Annotations

Domain (FT)

34..132; Cadherin 1; 137..241; Cadherin 2; 246..346; Cadherin 3; 351..450; Cadherin 4; 455..560; Cadherin 5; 567..670; Cadherin 6

Clinical Relevance1

Antibody

HPA014466

Supporting Publications4

PMID	Title	Abstract
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
40928027	Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.	No abstract available