Protein detail

PCDB4

Protocadherin beta-4 (PCDH-beta-4)

Entry name PCDB4	UniProt ID Q9Y5E5	EVMP confidence score 0.40
Supporting publications (n) 4	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

Protocadherin beta-4 (PCDH-beta-4)

Protein Class

Predicted membrane proteins

Transmembrane

690..710; Helical

Transmembrane Count

Ensembl

ENSG00000081818

Entrez Gene Symbol

PCDHB4

Gene Synonym

PCDH-BETA4

Gene Description

Protocadherin beta 4

Chromosome

Position

141121818-141125623

Supporting publications (n)

EVMP confidence score

0.40

Function & Pathway

Cellular Component (3)

Molecular Function

GO:0005509 calcium ion binding

Biological Process

GO:0008150 biological_process

KEGG

hsa04519 Cadherin signaling

Canonical Pathways (3)

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence30

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Plasma Membrane (Transmembrane)
plasma_membrane	plasma_membrane	OmniPath	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	Yes
cell_surface	cell_surface	Surfaceome	Yes
cell_surface	cell_surface	OmniPath	Yes
transmembrane	transmembrane_predicted	Phobius	Yes
transmembrane_phobius	transmembrane_predicted	Almen2009	Yes
transmembrane_sosui	transmembrane_predicted	Almen2009	Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009	Yes

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometry	6	38225453 39873726 38731868 30071318 27312428 40091455

Sequence, Structure & Domains

Sequences

Length

795

Mass

87,270

Sequence

MKKLGRIHPNRQVLAFILMVFLSQVRLEPIRYSVLEETESGSFVAHLAKDLGLGIGELASRSARVLSDDDKQRLQLDRQTGDLLLREKLDREELCGPIEPCVLHFQVFLEMPVQFFQGELLIQDINDHSPIFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITIAVTDLGTPRLKTQQNITVQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDTNDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGDSGTGEFKFLKPIFPNLLVQDTGREVKENPKFRNSLVFS

Domain & Motif Annotations

Domain (FT)

34..132; Cadherin 1; 137..241; Cadherin 2; 246..346; Cadherin 3; 351..450; Cadherin 4; 455..560; Cadherin 5; 567..670; Cadherin 6

Clinical Relevance

Antibody

HPA014466

Supporting Publications4

PMID	Title	Related sentences
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No related sentences available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No related sentences available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No related sentences available
40928027	Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.	No related sentences available