Protein detail

PCDBC

Protocadherin beta-12 (PCDH-beta-12)

Entry name PCDBC	UniProt ID Q9Y5F1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protocadherin beta-12 (PCDH-beta-12)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

691..711; Helical

Transmembrane Count

Ensembl

ENSG00000120328

Entrez Gene Symbol

PCDHB12

Gene Synonym

PCDH-BETA12

Gene Description

Protocadherin beta 12

Chromosome

Position

141208697-141212571

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Canonical Pathways

M34 Pid tcr pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence31

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
beta_protocadherin	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PCDHB12 PCDHB7	Q9Y5E2 Q9Y5F1	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	2	40098346 37922300

Sequence, Structure & Domains6

Sequences

Length

795

Mass

86,770

Sequence

MENGGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGLEVSELSSRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAPVGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTGSEVEENPPFQNNLGF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5F1-1; Sequence=Displayed; Name=2; IsoId=Q9Y5F1-2; Sequence=VSP_053862

Alternative Sequence

1..337; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

35..133; Cadherin 1; 138..242; Cadherin 2; 247..347; Cadherin 3; 352..451; Cadherin 4; 456..561; Cadherin 5; 568..671; Cadherin 6

Clinical Relevance1

Antibody

HPA045042

Supporting Publications1

PMID	Title	Abstract
31414377	Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.	No abstract available