Protein detail

PCDBC

Protocadherin beta-12 (PCDH-beta-12)

Entry name PCDBC	UniProt ID Q9Y5F1	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Protocadherin beta-12 (PCDH-beta-12)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

691..711; Helical

Transmembrane Count

Ensembl

ENSG00000120328

Entrez Gene Symbol

PCDHB12

Gene Synonym

PCDH-BETA12

Gene Description

Protocadherin beta 12

Chromosome

Position

141208697-141212571

Supporting publications (n)

EVMP confidence score

0.40

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Canonical Pathways

M34 Pid tcr pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence31

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Plasma Membrane (Transmembrane)
cell_adhesion	cell_adhesion	Almen2009	Yes	Yes	Yes
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	Yes
adhesion	adhesion	OmniPath	Yes	Yes	Yes
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes
transmembrane	transmembrane	UniProt_location			Yes
transmembrane	transmembrane	UniProt_topology			Yes
transmembrane	transmembrane	UniProt_keyword			Yes
transmembrane_predicted	transmembrane	OmniPath			Yes
transmembrane	transmembrane	OmniPath			Yes
plasma_membrane	plasma_membrane	UniProt_location			Yes

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PCDHB12 PCDHB7	Q9Y5E2 Q9Y5F1	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	2	40098346 37922300

Sequence, Structure & Domains

Sequences

Length

795

Mass

86,770

Sequence

MENGGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGLEVSELSSRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIELQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHFHVKIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSPEFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGDITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITVSSITSPIPENTPETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRDSGTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAAPVGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTGSEVEENPPFQNNLGF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5F1-1; Sequence=Displayed; Name=2; IsoId=Q9Y5F1-2; Sequence=VSP_053862

Alternative Sequence

1..337; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

35..133; Cadherin 1; 138..242; Cadherin 2; 247..347; Cadherin 3; 352..451; Cadherin 4; 456..561; Cadherin 5; 568..671; Cadherin 6

Clinical Relevance

Antibody

HPA045042

Supporting Publications1

PMID	Title	Related sentences
31414377	Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.	No related sentences available