Protein detail

PCDGJ

Protocadherin gamma-B7 (PCDH-gamma-B7)

Entry name PCDGJ	UniProt ID Q9Y5F8	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin gamma-B7 (PCDH-gamma-B7)

Protein Class

Predicted membrane proteins

Transmembrane

692..712; Helical

Transmembrane Count

Ensembl

ENSG00000254122

Entrez Gene Symbol

PCDHGB7

Gene Synonym (2)

ME6PCDH-GAMMA-B7

Gene Description

Protocadherin gamma subfamily B, 7

Chromosome

Position

141417645-141512975

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificNeutrophilsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway6

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Canonical Pathways (3)

M13 Pid erbb4 pathway
M236 Pid delta np63 pathway
M256 Pid tap63 pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence27

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No

Page 1 of 3Next

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDA2	Q9Y5H9	PCDGJ	Q9Y5F8	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDAA	Q9Y5I2	PCDGJ	Q9Y5F8	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38343172

Sequence, Structure & Domains8

Sequences

Length

929

Mass

100,974

Sequence

MGGSCAQRRRAGPRQVLFPLLLPLFYPTLCEPIRYSIPEELAKGSVVGNLAKDLGLSVLDVSARELRVSAEKLHFSVDAQSGDLLVKDRIDREQICKERRRCELQLEAVVENPLNIFHVIVVIEDVNDHAPQFRKDEINLEISESVSLGMGTILESAEDPDISMNSLSKYQLSPNEYFSLVEKDNPDGGKYPELVLQKTLDRETQSAHHLVLTALDGGDPPRSGTAQIRILVIDANDNPPVFSQDVYRVSLREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFEEVERYTINIEAKDRGSLSTRCKVIVEVVDENDNSPEIIITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSRGVPFKIHSSSNNYYKLVTDEALDREQTPEYNVTIAATDRGKPPLSSSKTITLHITDVNDNAPVFGQSAYLVHVPENNQPGASIAQVSASDPDFGLNGRVSYSLIASDLESRTLSSYVSVSAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDTVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVVQASEPGLFSLGLRTGEVRMVRALGDKDSVRQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDFSDHPTPSDSQAEMQFYLVVALALISVLFLLAVILAIALRLRQSFSPTAGDCFESVLCSKSGPVGPPNYSEGTLPYAYNFCVPGDQMNPEFNFFTSVDHCPATQDNLNKDSMLLASILTPSVEADKKILKQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5F8-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5F8-2; Sequence=VSP_008696, VSP_008697

Alternative Sequence

806..808; QAP -> VSI (in isoform 2); 809..929; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

807..838; Polar residues; 919..929; Basic residues

Domain (FT)

31..133; Cadherin 1; 134..242; Cadherin 2; 243..347; Cadherin 3; 348..452; Cadherin 4; 453..562; Cadherin 5; 570..675; Cadherin 6

Region

806..838; Disordered; 899..929; Disordered

Clinical Relevance1

Antibody (2)

HPA008755 HPA010580

Supporting Publications4

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28590090	Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.	No abstract available
32284825	Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available