Protein detail
PCDG4
Protocadherin gamma-A4 (PCDH-gamma-A4)
Entry name PCDG4 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protocadherin gamma-A4 (PCDH-gamma-A4)
Protein Class
Predicted membrane proteins
Transmembrane
724..744; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PCDH-GAMMA-A4
Gene Description
Protocadherin gamma subfamily A, 4
Chromosome
5
Position
141355021-141512975
Supporting publications (n)
4
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificOocytesSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Cellular Component
Molecular Function (2)
Biological Process (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence27
Ligand-Receptor Signaling (24)
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | Yes | |||
| protocadherin | cell_adhesion | HGNC | Yes | Yes | Yes | ||
| adhesion | adhesion | HGNC | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | Yes | ||
| icam | cell_adhesion | Zhong2015 | Yes | Yes | Yes |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDAA | Q9Y5I2 | PCDG4 | Q9Y5G9 | Yes | Yes | SIGNOR | SIGNOR:16697637 | |
| PCDA2 | Q9Y5H9 | PCDG4 | Q9Y5G9 | Yes | Yes | SIGNOR | SIGNOR:16697637 |
Sequence, Structure & Domains
Sequences
Length
962
Mass
103,968
Sequence
MHFILDPEDPGAPQASTEGKPKHRRLRGGVVMAAPPARPDHTRLLQICLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKPSADPDDSGLTLYLVVAVAAVSCVFLAFVTVLLALKLRRWHKSRLLHAEGSRLAGVPASHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFSQPSYADTLISRESCEKSEPLLITQDLLETKGDPNLQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5G9-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G9-2; Sequence=VSP_008665, VSP_008666
Alternative Sequence
839..851; QAPPNTDWRFSQA -> VSQSYNRSYHTEI (in isoform 2); 852..962; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
836..871; Polar residues; 952..962; Basic residues
Domain (FT)
60..164; Cadherin 1; 165..273; Cadherin 2; 274..378; Cadherin 3; 379..483; Cadherin 4; 484..598; Cadherin 5; 601..713; Cadherin 6
Region
1..24; Disordered; 832..871; Disordered; 932..962; Disordered
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |
| 41073401 | Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids. | No related sentences available |