Protein detail
PCDG4
Protocadherin gamma-A4 (PCDH-gamma-A4)
Protein symbol PCDG4 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Basic Information
Protein Names
Protocadherin gamma-A4 (PCDH-gamma-A4)
Protein Class
Predicted membrane proteins
Transmembrane
724..744; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PCDH-GAMMA-A4
Gene Description
Protocadherin gamma subfamily A, 4
Chromosome
5
Position
141355021-141512975
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificOocytesSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDAA | Q9Y5I2 | PCDG4 | Q9Y5G9 | Yes | Yes | No | SIGNOR | SIGNOR:16697637 |
| PCDA2 | Q9Y5H9 | PCDG4 | Q9Y5G9 | Yes | Yes | No | SIGNOR | SIGNOR:16697637 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
962
Mass
103,968
Sequence
MHFILDPEDPGAPQASTEGKPKHRRLRGGVVMAAPPARPDHTRLLQICLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKPSADPDDSGLTLYLVVAVAAVSCVFLAFVTVLLALKLRRWHKSRLLHAEGSRLAGVPASHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFSQPSYADTLISRESCEKSEPLLITQDLLETKGDPNLQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5G9-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G9-2; Sequence=VSP_008665, VSP_008666
Alternative Sequence
839..851; QAPPNTDWRFSQA -> VSQSYNRSYHTEI (in isoform 2); 852..962; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
836..871; Polar residues; 952..962; Basic residues
Domain (FT)
60..164; Cadherin 1; 165..273; Cadherin 2; 274..378; Cadherin 3; 379..483; Cadherin 4; 484..598; Cadherin 5; 601..713; Cadherin 6
Region
1..24; Disordered; 832..871; Disordered; 932..962; Disordered