Protein detail

PCDG4

Protocadherin gamma-A4 (PCDH-gamma-A4)

Entry name PCDG4	UniProt ID Q9Y5G9	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin gamma-A4 (PCDH-gamma-A4)

Protein Class

Predicted membrane proteins

Transmembrane

724..744; Helical

Transmembrane Count

Ensembl

ENSG00000262576

Entrez Gene Symbol

PCDHGA4

Gene Synonym

PCDH-GAMMA-A4

Gene Description

Protocadherin gamma subfamily A, 4

Chromosome

Position

141355021-141512975

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificskin 1Cell SpecificOocytesSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway5

Cellular Component

GO:0005886 plasma membrane

Molecular Function (2)

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence27

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDAA	Q9Y5I2	PCDG4	Q9Y5G9	Yes	Yes	No	SIGNOR	SIGNOR:16697637
PCDA2	Q9Y5H9	PCDG4	Q9Y5G9	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	38225453 40311616

Sequence, Structure & Domains8

Sequences

Length

962

Mass

103,968

Sequence

MHFILDPEDPGAPQASTEGKPKHRRLRGGVVMAAPPARPDHTRLLQICLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKPSADPDDSGLTLYLVVAVAAVSCVFLAFVTVLLALKLRRWHKSRLLHAEGSRLAGVPASHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFSQPSYADTLISRESCEKSEPLLITQDLLETKGDPNLQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5G9-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G9-2; Sequence=VSP_008665, VSP_008666

Alternative Sequence

839..851; QAPPNTDWRFSQA -> VSQSYNRSYHTEI (in isoform 2); 852..962; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

836..871; Polar residues; 952..962; Basic residues

Domain (FT)

60..164; Cadherin 1; 165..273; Cadherin 2; 274..378; Cadherin 3; 379..483; Cadherin 4; 484..598; Cadherin 5; 601..713; Cadherin 6

Region

1..24; Disordered; 832..871; Disordered; 932..962; Disordered

Clinical Relevance1

Antibody (2)

HPA008755 HPA010580

Supporting Publications4

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
41073401	Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids.	No abstract available