Protein detail

PCDA5

Protocadherin alpha-5 (PCDH-alpha-5)

Entry name PCDA5	UniProt ID Q9Y5H7	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protocadherin alpha-5 (PCDH-alpha-5)

Protein Class

Predicted membrane proteins

Transmembrane

697..717; Helical

Transmembrane Count

Ensembl

ENSG00000204965

Entrez Gene Symbol

PCDHA5

Gene Synonym (5)

CNR6CNRN6CNRS6CRNR6PCDH-ALPHA5

Gene Description

Protocadherin alpha 5

Chromosome

Position

140821604-141012347

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence25

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
protocadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCDA5	Q9Y5H7	ITB1	P05556	Yes	Yes	No	SIGNOR	SIGNOR:16697637

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	26	40189497 26826536 40985879 36064647 38113368 40465195 37322475 33304478 36497184 34064677 41068253 33592500 34473505 32916986 41307968 36146834 40840701 31805958 32230970 38207106 34576246 37204515 39207047 32854315 37926756 40831280

Sequence, Structure & Domains9

Sequences

Length

936

Mass

102,048

Sequence

MVYSRRGSLGSRLLLLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAQPTEAVCTRGKPTLLCSSAVGSWSYSQQRRQRVCSGEAPPKTDLMAFSPSLPQGPTSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y5H7-1; Sequence=Displayed; Name=2; IsoId=Q9Y5H7-2; Sequence=VSP_000679, VSP_000680; Name=3; IsoId=Q9Y5H7-3; Sequence=VSP_008704, VSP_008705

Alternative Sequence

785..816; PRQPNPDWRYSASLRAGMHSSVHLEEAGILRA -> VSFLILTSIFPSQFSNIKCHIHPLFLYLKIMS (in isoform 2); 817..936; Missing (in isoform 2); 868..890; GELPDKFIIPGSPAIISIRQEPT -> EPKKQTQVSFLLRRKGEASQPRQ (in isoform 3); 891..936; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

774..786; Polar residues; 895..909; Basic and acidic residues

Repeat

773..776; PXXP 1; 785..788; PXXP 2; 818..821; PXXP 3; 873..876; PXXP 4; 877..890; PXXP 5

Domain (FT)

33..132; Cadherin 1; 156..241; Cadherin 2; 242..349; Cadherin 3; 350..454; Cadherin 4; 455..564; Cadherin 5; 580..677; Cadherin 6

Region

759..793; Disordered; 773..890; 5 X 4 AA repeats of P-X-X-P; 816..936; Disordered

Clinical Relevance1

Antibody

HPA044557

Supporting Publications1

PMID	Title	Abstract
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available