Protein detail
PCDA5
Protocadherin alpha-5 (PCDH-alpha-5)
Entry name PCDA5 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protocadherin alpha-5 (PCDH-alpha-5)
Protein Class
Predicted membrane proteins
Transmembrane
697..717; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CNR6CNRN6CNRS6CRNR6PCDH-ALPHA5
Gene Description
Protocadherin alpha 5
Chromosome
5
Position
140821604-141012347
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCDA5 | Q9Y5H7 | ITB1 | P05556 | Yes | Yes | No | SIGNOR | SIGNOR:16697637 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 26 | 4018949726826536409858793606464738113368404651953732247533304478364971843406467741068253335925003447350532916986413079683614683440840701318059583223097038207106345762463720451539207047328543153792675640831280 |
Sequence, Structure & Domains
Sequences
Length
936
Mass
102,048
Sequence
MVYSRRGSLGSRLLLLWLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAQPTEAVCTRGKPTLLCSSAVGSWSYSQQRRQRVCSGEAPPKTDLMAFSPSLPQGPTSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y5H7-1; Sequence=Displayed; Name=2; IsoId=Q9Y5H7-2; Sequence=VSP_000679, VSP_000680; Name=3; IsoId=Q9Y5H7-3; Sequence=VSP_008704, VSP_008705
Alternative Sequence
785..816; PRQPNPDWRYSASLRAGMHSSVHLEEAGILRA -> VSFLILTSIFPSQFSNIKCHIHPLFLYLKIMS (in isoform 2); 817..936; Missing (in isoform 2); 868..890; GELPDKFIIPGSPAIISIRQEPT -> EPKKQTQVSFLLRRKGEASQPRQ (in isoform 3); 891..936; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
774..786; Polar residues; 895..909; Basic and acidic residues
Repeat
773..776; PXXP 1; 785..788; PXXP 2; 818..821; PXXP 3; 873..876; PXXP 4; 877..890; PXXP 5
Domain (FT)
33..132; Cadherin 1; 156..241; Cadherin 2; 242..349; Cadherin 3; 350..454; Cadherin 4; 455..564; Cadherin 5; 580..677; Cadherin 6
Region
759..793; Disordered; 773..890; 5 X 4 AA repeats of P-X-X-P; 816..936; Disordered
Clinical Relevance
Antibody