Protein detail

CD2AP

CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)

Entry name CD2AP	UniProt ID Q9Y5K6	EVMP confidence score 0.75
Supporting publications (n) 30	Transmembrane count	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters

Protein Function (5)

Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Ensembl

ENSG00000198087

Entrez Gene Symbol

CD2AP

Gene Synonym

CMS

Gene Description

CD2 associated protein

Chromosome

Position

47477789-47627263

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization3

Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway7

Protein Function (5)

Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (19)

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Molecular Function (8)

Biological Process (3)

KEGG (2)

Reactome (2)

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence17

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CD2AP	Q9Y5K6	ACTB	P60709	Yes	Yes	No	SIGNOR	SIGNOR:29175910
FA83G	A6ND36	CD2AP	Q9Y5K6	Yes	Yes	No	SIGNOR	SIGNOR:29175910

Protein Complex Composition (7)

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Cbl-Cd2ap complex	CBL CD2AP	P22681 Q9Y5K6	1:1	Compleat	Compleat:HC850	15001553
	CD2AP NPHS1 NPHS2 PTCD1 SH3KBP1 YWHAZ	O60500 O75127 P63104 Q96B97 Q9NP85 Q9Y5K6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6787
	CBLB CD2AP	Q13191 Q9Y5K6	1:1	PDB	PDB:2j6f
	CD2AP MVB12B TSG101 VPS28 VPS37A VPS37B	Q8NEZ2 Q99816 Q9H7P6 Q9H9H4 Q9UK41 Q9Y5K6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5006
	CD2AP RIN3	Q8TB24 Q9Y5K6	3:3	PDB	PDB:4wciPDB:3u23
	CD2AP NUDC	Q9Y266 Q9Y5K6	0:0	hu.MAP
	CD2AP	Q9Y5K6	12	PDB	PDB:2j6k

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	4	38113368 40189497 32560723 38207106

Sequence, Structure & Domains12

Sequences

Length

639

Mass

71,451

Sequence

MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS

3D Structural Models

Helix

159..161; 489..492; 503..505

Beta Strand

4..6; 25..30; 37..42; 45..50; 53..56; 112..115; 134..142; 145..150; 153..158; 162..164

3D Structure

NMR spectroscopy (1); X-ray crystallography (11)

Domain & Motif Annotations

Compositional Bias

168..177; Basic and acidic residues; 195..207; Polar residues; 341..351; Pro residues; 356..379; Basic and acidic residues; 385..395; Pro residues

Motif

336..352; SH3-binding; 378..397; SH3-binding; 410..422; SH3-binding

Coiled Coil

577..638

Domain (CC)

The Pro-rich domain may mediate binding to SH3 domains.; DOMAIN: Potential homodimerization is mediated by the coiled coil domain.

Domain (FT)

1..59; SH3 1; truncated; 108..167; SH3 2; 269..330; SH3 3

Region

1..175; Interaction with ANLN and localization to the midbody; 168..209; Disordered; 227..256; Disordered; 333..428; Disordered

Clinical Relevance4

Antibody (3)

HPA003267 HPA003326 CAB004352

Interaction Protein (10)

ENSG00000077549ENSG00000095585ENSG00000100599ENSG00000110395ENSG00000114423ENSG00000116824ENSG00000147010ENSG00000170248ENSG00000177885ENSG00000198898

Interaction Count

Interaction Dataset (3)

biogrid_opencellintact_biogridbiogrid_bioplex

Supporting Publications30

PMID	Title	Abstract
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
32916986	Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines.	No abstract available
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
33936570	Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography.	No abstract available
34064677	Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.	No abstract available

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