Protein detail
CD2AP
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Protein symbol CD2AP | UniProt ID | EVMP score 0.75 |
Frequency 30 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters |
Basic Information
Protein Names
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function
- Human disease related genes:Urinary system diseases:Kidney diseases
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
CMS
Gene Description
CD2 associated protein
Chromosome
6
Position
47477789-47627263
Frequency
30
EVMP Score
0.75
Fluorescence & Localization
Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Human disease related genes:Urinary system diseases:Kidney diseases
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component
- GO:0001650 fibrillar center
- GO:0001726 ruffle
- GO:0002102 podosome
- GO:0005641 nuclear envelope lumen
- GO:0005737 cytoplasm
- GO:0005770 late endosome
- GO:0005886 plasma membrane
- GO:0015629 actin cytoskeleton
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0030426 growth cone
- GO:0031252 cell leading edge
- GO:0031594 neuromuscular junction
- GO:0031941 filamentous actin
- GO:0031982 vesicle
- GO:0032588 trans-Golgi network membrane
- GO:0034451 centriolar satellite
- GO:0036057 slit diaphragm
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CD2AP | Q9Y5K6 | ACTB | P60709 | Yes | Yes | No | SIGNOR | SIGNOR:29175910 |
| FA83G | A6ND36 | CD2AP | Q9Y5K6 | Yes | Yes | No | SIGNOR | SIGNOR:29175910 |
Protein Complex Composition
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Cbl-Cd2ap complex | CBLCD2AP | P22681Q9Y5K6 | 1:1 | Compleat | Compleat:HC850 | 15001553 |
| CD2APNPHS1NPHS2PTCD1SH3KBP1YWHAZ | O60500O75127P63104Q96B97Q9NP85Q9Y5K6 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6787 | ||
| CBLBCD2AP | Q13191Q9Y5K6 | 1:1 | PDB | PDB:2j6f | ||
| CD2APMVB12BTSG101VPS28VPS37AVPS37B | Q8NEZ2Q99816Q9H7P6Q9H9H4Q9UK41Q9Y5K6 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5006 | ||
| CD2APRIN3 | Q8TB24Q9Y5K6 | 3:3 | PDB | PDB:4wciPDB:3u23 | ||
| CD2APNUDC | Q9Y266Q9Y5K6 | 0:0 | hu.MAP | |||
| CD2AP | Q9Y5K6 | 12 | PDB | PDB:2j6k |
Sequence, Structure & Domains
Sequences
Length
639
Mass
71,451
Sequence
MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS
3D Structural Models
Helix
159..161; 489..492; 503..505
Beta Strand
4..6; 25..30; 37..42; 45..50; 53..56; 112..115; 134..142; 145..150; 153..158; 162..164
3D Structure
NMR spectroscopy (1); X-ray crystallography (11)
Domain & Motif Annotations
Compositional Bias
168..177; Basic and acidic residues; 195..207; Polar residues; 341..351; Pro residues; 356..379; Basic and acidic residues; 385..395; Pro residues
Motif
336..352; SH3-binding; 378..397; SH3-binding; 410..422; SH3-binding
Coiled Coil
577..638
Domain (CC)
The Pro-rich domain may mediate binding to SH3 domains.; DOMAIN: Potential homodimerization is mediated by the coiled coil domain.
Domain (FT)
1..59; SH3 1; truncated; 108..167; SH3 2; 269..330; SH3 3
Region
1..175; Interaction with ANLN and localization to the midbody; 168..209; Disordered; 227..256; Disordered; 333..428; Disordered